ArticleEuropean journal of internal medicine2022
Pulmonary embolism severity and in-hospital mortality: An international comparative study between COVID-19 and non-COVID patients.
Article in European journal of internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 18 citations in OpenAlex.
- Mortality rate and factors associated with in-hospital mortality in patients hospitalized with pulmonary embolism in Germany.Journal of thrombosis and thrombolysis · 2024Article
- Validity of mortality risk prediction scores in critically ill patients with secondary pulmonary embolism.Biomolecules & biomedicine · 2024Article
- Predictive value of hematological indices on incidence and severity of pulmonary embolism in COVID-19 patients.Immunity, inflammation and disease · 2023Article
- Impact of Alteplase on Mortality in Critically Ill Patients with COVID-19 and Pulmonary Embolism.Viruses · 2023Article
- Clinical characteristics of COVID-19 associated vasculopathic diseases.Thrombosis journal · 2023Review
- Acute phase characteristics and long-term complications of pulmonary embolism in COVID-19 compared to non-COVID-19 cohort: a large single-centre study.BMC pulmonary medicine · 2023Article
- Characteristics and outcomes of sepsis patients with and without COVID-19.Journal of infection and public health · 2022Article
- Validation of the PESI Scale to Predict in-Hospital Mortality in Patients with Pulmonary Thromboembolism Secondary to SARS CoV - 2 Infection.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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17 authors at 11 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the severity of pulmonary embolism (PE) between patients with and without COVID, and to assess the association between severity and in-hospital-mortality.
methodsWe performed an analysis of 549 COVID (71.3% PCR-confirmed) and 439 non-COVID patients with PE consecutively included by 62 Spanish and 16 French emergency departments. PE-severity was assessed by size, the presence of right ventricular dysfunction (RVD), and the sPESI. The association of PE-severity and in-hospital-mortality was assessed both in COVID and non-COVID patients, and the interaction of COVID status and PE severity/outcome associations was also evaluated.
resultsCOVID patients had PEs of smaller size (43% vs 56% lobar or larger, 42% vs. 35% segmental and 13% vs. 9% subsegmental, respectively; p = 0.01 for trend), less RVD (22% vs. 16%, p =0.02) and lower sPESI (p =0.03 for trend). Risk of in-hospital death was higher in COVID patients (12.8% vs. 5.3%, p < 0.001). PE-severity assessed by RVD and sPESI was independently associated with in-hospital-mortality in COVID patients, while PE size and sPESI were significantly associated with in-hospital-mortality in non-COVID. COVID status showed a significant interaction in the association of PE size and outcome (p =0.01), with OR for in-hospital mortality in COVID and non-COVID patients with lobar or larger PE of 0.92 (95%CI=0.19-4.47) and 4.47 (95%CI=1.60-12.5), respectively. Sensitivity analyses using only PCR-confirmed COVID cases confirmed these results.
conclusionCOVID patients present a differential clinical picture, with PE of less severity than in non-COVID patients. An increased sPESI was associated with the risk of mortality in both groups but, PE size did not seem to be associated with in-hospital mortality in COVID patients.
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