Evidence map›Paper›PMID 35115030›Full record

SynthesisAntimicrobial resistance and infection control2022

Education level and misuse of antibiotics in the general population: a systematic review and dose-response meta-analysis.

Narmeen Mallah, Nicola Orsini, Adolfo Figueiras, Bahi Takkouche

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Antimicrobial resistance and infection control, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Narmeen MallahDepartment of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Nicola OrsiniDepartment of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Adolfo FigueirasDepartment of Preventive Medicine, University of Santiago de Compostela, R/ San Francisco, s/n, 15782, Santiago de Compostela, Spain.
Bahi TakkoucheDepartment of Preventive Medicine, University of Santiago de Compostela, R/ San Francisco, s/n, 15782, Santiago de Compostela, Spain. bahi.takkouche@usc.es.ORCID 0000-0002-0739-2241
Universidade de Santiago de Compostela · ESKarolinska Institutet · SE

Funding

Erasmus European Mobility Program Erasmus+ KA103 (2020/2021)Regional Ministry of Education, Universities and Vocational Training, Santiago de Compostela, Spain ED431C 2018/20
6 · The paper itself

Abstract

backgroundNumerous studies evaluated the association of education level with misuse of antibiotics by the general population, yet divergent findings were reported. Therefore, a meta-analysis was conducted to summarize this association.

methodsA categorical and continuous dose-response meta-analysis of the association of education level with antibiotic misuse was undertaken. Summary odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated using random-effect model.

resultsThe meta-analysis included 85 studies from 42 countries of different socioeconomic status. Compared to low education (≤ 9 years), medium education (> 9-12 years) is associated with 20% lower odds of antibiotic misuse in high-income countries (OR = 0.80; 95% CI 0.66, 0.97), while high education (> 12 years) is associated with 14% lower odds of any aspect of antibiotic misuse (OR = 0.86; 95% CI 0.72, 1.03). The association is more pronounced in Middle East (OR = 0.64; 95% CI 0.42, 1.00) and countries of lower-middle economies (OR = 0.67, 95% CI 0.41, 1.11). Inversely, in Europe, high education is associated with 25% higher odds of antibiotic misuse (OR = 1.25, 95% CI 1.00, 1.58). Each additional year of education was associated with 4% lower odds of any aspect of antibiotic misuse in lower-middle economies (OR = 0.96; 95% CI 0.92, 1.00) and in Middle East (OR = 0.96; 95% CI 0.93, 1.00). Conversely, it was associated with 3% higher odds of antibiotic storage, a specific type of misuse (OR = 1.03, 95% CI 1.01, 1.06).

conclusionIndividuals misuse antibiotics irrespective of their education level. Intervention programs to enhance the proper use of antibiotics should target all communities independent of their education level.

Indexed as

Dose-Response Relationship, DrugEducational StatusAnti-Bacterial AgentsDrug MisuseHumansAnti-Bacterial AgentsAntibioticDose–responseEducationMeta-analysisMisuse

Identifiers

PMID35115030
PMCPMC8815169
OpenAlexW4210382599

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.