ArticleReproductive biology and endocrinology : RB&E2022
Gonadotropin-releasing hormone agonist downregulation combined with hormone replacement therapy improves the reproductive outcome in frozen-thawed embryo transfer cycles for patients of advanced reproductive age with idiopathic recurrent implantation failure.
Article in Reproductive biology and endocrinology : RB&E, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Intrauterine infusion of oil-based medium in women with recurrent implantation failure before frozen embryo transfer: a randomized clinical trial.Reproductive health · 2025Trial
- Duration of progesterone exposure before frozen embryo transfer impacts live birth rates following single vitrified-thawed day 6 blastocyst transfer: a multicenter cohort study.Contraception and reproductive medicine · 2026Article
- Comparison of clinical outcomes between use of estradiol transdermal gel and oral estradiol valerate in patients undergoing frozen-thaw embryo transfer: an observational study.Archives of gynecology and obstetrics · 2025Observational
- The impact of operative hysteroscopy on pregnancy outcomes in patients with suspected uterine cavity lesions prior to the first frozen-thawed embryo transfer: a retrospective propensity-score matching cohort study.European journal of medical research · 2025Article
- GnRH-a use before programmed frozen embryo transfer cycles for women with PCOS: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2025Article
- Preimplantation genetic testing for aneuploidy on previously cryopreserved unbiopsied blastocysts: a cohort study in women with IVF pregnancy loss.Reproductive biology and endocrinology : RB&E · 2025Observational
- The impact of long-acting Gonadotropin-releasing hormone agonist pretreatment on the clinical pregnancy outcomes of hormone replacement therapy-frozen embryo transfer in recurrent implantation failure patients with and without polycystic ovary syndrome: a retrospective clinical study.BMC pregnancy and childbirth · 2025Article
- Impact of GnRH Agonist Pretreatment on Frozen-Thawed Embryo Transfer Outcomes of Overweight/Obese Women Undergoing Hormone Replacement Therapy.Drug design, development and therapy · 2025Article
- Acupuncture combined with gonadotropin-releasing hormone agonists improves endometrial receptivity and pregnancy outcome in patients with recurrent implantation failure of in vitro fertilization-embryo transfer.Journal of assisted reproduction and genetics · 2024Article
- Non-invasive evaluation of endometrial microvessels via in vivo intrauterine photoacoustic endoscopy.Photoacoustics · 2024Article
- Review
- The effect of gonadotropin-releasing hormone agonist downregulation in conjunction with hormone replacement therapy on endometrial preparation in patients for frozen-thawed embryo transfer.Frontiers in medicine · 2024Article
- The Role of Dydrogesterone in the Management of Luteal Phase Defect: A Comprehensive Review.Cureus · 2023Review
- Preparation of the endometrium for frozen embryo transfer: an update on clinical practices.Reproductive biology and endocrinology : RB&E · 2023Review
- Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway.Journal of assisted reproduction and genetics · 2023Article
- Additional single dose GnRH agonist during luteal phase support may improve live birth rate in GnRHa-HRT frozen-thawed embryo transfer cycle: a retrospective cohort study.BMC pregnancy and childbirth · 2023Article
- ESHRE good practice recommendations on recurrent implantation failure.Human reproduction open · 2023Article
- Article
- Endometrial thickness is associated with low birthweight in frozen embryo transfer cycles: A retrospective cohort study of 8,235 singleton newborns.Frontiers in endocrinology · 2022Article
- The Asian Society of Endometriosis and Adenomyosis guidelines for managing adenomyosis.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTo determine whether gonadotropin-releasing hormone (GnRH) agonist downregulation combined with hormone replacement therapy (HRT) can improve the reproductive outcomes in frozen-thawed embryo transfer cycles for older patients (aged 36-43 years) with idiopathic recurrent implantation failure (RIF).
methodsThis retrospective cohort study involved 549 older patients undergoing their third cleavage-stage embryo or blastocyst transfer over a 5-year period (January 2015-December 2020) at Northwest Women's and Children's Hospital after in vitro fertilization/intracytoplasmic sperm injection cycles. Patients with known endometriosis or adenomyosis were excluded from the study. The patients were divided into three groups according to the endometrial preparation protocol: the natural cycle (NC) group (n = 65), the HRT group (n = 194), and the GnRH agonist downregulation combined with HRT cycle (GnRH agonist-HRT) group (n = 290). The primary outcome was the live birth rate, and the secondary outcomes were the clinical pregnancy, miscarriage, and ongoing pregnancy rates.
resultsThe live birth rate in the GnRH agonist-HRT group (36.55%) was higher than that in the HRT group (22.16%) and NC group (16.92%) (P < 0.0001). Similarly, a logistic regression model adjusting for potential confounders showed that the live birth rate was higher in the GnRH agonist-HRT group than in the HRT group (odds ratio, 0.594; 95% confidence interval, 0.381-0.926; P = 0.021) and NC group (odds ratio, 0.380; 95% confidence interval, 0.181-0.796; P = 0.010).
conclusionsThe GnRH agonist-HRT protocol improves the live birth rate in frozen-thawed embryo transfer cycles for patients of advanced reproductive age with RIF. We hypothesize that the GnRH agonist-HRT protocol enhances implantation-related factors and promotes optimal endometrial receptivity, leading to an improved live birth rate. These findings are also useful for further investigating the underlying mechanism of the GnRH agonist-HRT protocol in improving the reproductive outcomes for patients of advanced reproductive age with RIF.
trial registrationThis research protocol was approved by the hospital institutional ethics committee (No. 2021002).
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