Evidence map›Paper›PMID 35114994›Full record

ArticleBMC medicine2022

Studying the post-COVID-19 condition: research challenges, strategies, and importance of Core Outcome Set development.

Daniel Munblit, Timothy R Nicholson, Dale M Needham, Nina Seylanova, Callum Parr, Jessica Chen, Alisa Kokorina, Louise Sigfrid, Danilo Buonsenso, Shinjini Bhatnagar and 29 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 4 pooled it
17.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 4 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
  2. Neurological manifestations associated with SARS-CoV-2 infection in pediatric patients: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025
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  15. Long Covid Symptom Clusters, Correlates and Predictors in a Highly Vaccinated Australian Population in 2023.Health expectations : an international journal of public participation in health care and health policy · 2025
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  16. Review
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 20 institutions in 11 countries.

Daniel Munblit *Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. daniel.munblit08@imperial.ac.uk.ORCID 0000-0001-9652-6856
Timothy R Nicholson *Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Dale M Needham *Outcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University, Baltimore, MD, USA.
Nina Seylanova *Sechenov Biomedical Science and Technology Park, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Callum ParrFaculty of Medicine, Imperial College London, London, UK.
Jessica ChenFaculty of Medicine, Imperial College London, London, UK.
Alisa KokorinaPirogov Russian National Research Medical University, Moscow, Russia.
Louise SigfridISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
Danilo BuonsensoDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Shinjini BhatnagarMaternal and Child Health Program, Translational Health Science and Technology Institute, Faridabad, Delhi, National Capital Region, India.
Ramachandran ThiruvengadamMaternal and Child Health Program, Translational Health Science and Technology Institute, Faridabad, Delhi, National Capital Region, India.
Ann M ParkerOutcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University, Baltimore, MD, USA.
Jacobus PrellerClinical Management, WHO, WHE, Geneva, Switzerland.
Sergey AvdeevDepartment of Pulmonology, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Frederikus A KlokDepartment of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.
Allison TongSydney School of Public Health, The University of Sydney, Sydney, Australia.
Janet V DiazNCD Department, Rehabilitation Programme, WHO, Geneva, Switzerland.
Wouter De GrooteNCD Department, Rehabilitation Programme, WHO, Geneva, Switzerland.
Nicoline SchiessWHO Brain Health Unit, Geneva, Switzerland.
Athena AkramiSainsbury Wellcome Centre, UCL, London, UK.
Frances SimpsonCoventry University, Coventry, UK.
Piero OlliaroISARIC Global Support Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Christian ApfelbacherInstitute of Social Medicine and Health Systems Research, Faculty of Medicine, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Regis Goulart RosaCritical Care Department, Hospital Moinhos de Vento, Porto Alegre, Brazil.
Jennifer R ChevinskyCOVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Sharon SaydahCOVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Jochen SchmittCenter for Evidence-Based Healthcare, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany.
Alla GuekhtResearch and Clinical Center for Neuropsychiatry, Moscow, Russia.
Sarah L GorstDepartment of Health Data Science, University of Liverpool, Liverpool, UK.
Jon GenuneitPaediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Leipzig, Germany.
Luis Felipe ReyesUniversidad de La Sabana, Chía, Colombia.
Alan AsmanovThe Research and Clinical Institute for Pediatrics named after Academician Yuri Veltischev of the Pirogov Russian National Research Medical University, Moscow, Russia.
Margaret E O'HaraLong COVID Support, London, UK.
Janet T ScottMRC-University of Glasgow, Centre for Virus Research, Glasgow, UK.
Melina MichelenISARIC Global Support Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Charitini StavropoulouSchool of Health Sciences, City, University of London, London, UK.
John O WarnerPaediatric Infectious Diseases, Imperial College Healthcare NHS Trust, London, UK.
Margaret HerridgeInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Paula R Williamson *MRC/NIHR Trials Methodology Research Partnership, Department of Health Data Science, University of Liverpool (a member of Liverpool Health Partners), Liverpool, UK.
Pirogov Russian National Research Medical University · RUSechenov University · RUCenters for Disease Control and Prevention · USCity, University of London · GBImperial College London · GBJohns Hopkins University · USTranslational Health Science and Technology Institute · INUniversity of Liverpool · GBCoventry University · GBHospital Moinhos de Vento · BRImperial College Healthcare NHS Trust · GBKing's College London · GBLeiden University Medical Center · NLLeipzig University · DEMRC University of Glasgow Centre for Virus Research · GBOtto-von-Guericke-Universität Magdeburg · DESainsbury Laboratory · GBThe University of Sydney · AUUniversidad de La Sabana · COUniversità Cattolica del Sacro Cuore · IT

Funding

Medical Research Council MC_PC_19026World Health Organization 001
6 · The paper itself

Abstract

backgroundA substantial portion of people with COVID-19 subsequently experience lasting symptoms including fatigue, shortness of breath, and neurological complaints such as cognitive dysfunction many months after acute infection. Emerging evidence suggests that this condition, commonly referred to as long COVID but also known as post-acute sequelae of SARS-CoV-2 infection (PASC) or post-COVID-19 condition, could become a significant global health burden. MAIN TEXT: While the number of studies investigating the post-COVID-19 condition is increasing, there is no agreement on how this new disease should be defined and diagnosed in clinical practice and what relevant outcomes to measure. There is an urgent need to optimise and standardise outcome measures for this important patient group both for clinical services and for research and to allow comparing and pooling of data.

conclusionsA Core Outcome Set for post-COVID-19 condition should be developed in the shortest time frame possible, for improvement in data quality, harmonisation, and comparability between different geographical locations. We call for a global initiative, involving all relevant partners, including, but not limited to, healthcare professionals, researchers, methodologists, patients, and caregivers. We urge coordinated actions aiming to develop a Core Outcome Set (COS) for post-COVID-19 condition in both the adult and paediatric populations.

Indexed as

COVID-19AdultChildDisease ProgressionHumansOutcome Assessment, Health CarePost-Acute COVID-19 SyndromeSARS-CoV-2Core Outcome SetCOVID-19COVID-19 sequalaeLong COVIDOutcomesPASCPost-acute sequelae of SARS-CoV-2 infectionPost-COVID-19 condition

Identifiers

PMID35114994
PMCPMC8813480
OpenAlexW4210420930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.