Evidence map›Paper›PMID 35114852›Full record

ArticleJournal of dental research2022

MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling Activity.

J-M Lee, C Qin, O H Chai, Y Lan, R Jiang, H-J E Kwon

Open access · greenAbstract read
In one paragraph

Article in Journal of dental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Frontiers in physiology · 2026
    Article
  5. Genes & diseases · 2026
    Article
  6. Article
  7. KMT2D Regulates Tooth Enamel Development.Journal of dental research · 2025
    Article
  8. Article
  9. Article
  10. MLL4 regulates postnatal palate growth and midpalatal suture development.Frontiers in cell and developmental biology · 2025
    Article
  11. KMT2D regulates tooth enamel development.bioRxiv : the preprint server for biology · 2024
    Article
  12. MLL4 regulates postnatal palate growth and midpalatal suture development.bioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Thoughts on the Etiology of Cherubism.Journal of clinical medicine · 2024
    Article
  15. Observational
  16. Article
  17. Article
  18. Review
  19. Tooth number abnormality: from bench to bedside.International journal of oral science · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

J-M LeeDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA.
C QinDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
O H ChaiDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Y LanDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
R JiangDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-7842-4696
H-J E KwonDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA.ORCID 0000-0001-6538-6045
Cincinnati Children's Hospital Medical Center · USUniversity at Buffalo, State University of New York · US

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Institutional Career DevelopmentKL2TR001413 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DUBOCOVICH, MARGARITA L · 2015 to 2024
$4.2M
Advanced Training in Oral BiologyT32DE023526 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Stefan Hans-Klaus Ruhl · 2013 to 2026
$3.7M
Molecular Patterning of Mammalian DentitionR01DE018401 · NIDCR · UNIVERSITY OF ROCHESTER · PI JIANG, RULANG · 2009 to 2017
$3.4M
Mandible DevelopmentR01DE027046 · NIDCR · CINCINNATI CHILDRENS HOSP MED CTR · PI JIANG, RULANG · 2017 to 2021
$3.2M
Epigenetic regulatory roles of Mll4 in palate developmentR03DE030985 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI KWON, HYUK JAE EDWARD · 2021 to 2022
$319k
NCATS NIH HHS KL2 TR001413NCATS NIH HHS UL1 TR001412NIDCR NIH HHS R01 DE018401NIDCR NIH HHS R01 DE027046NIDCR NIH HHS R03 DE030985NIDCR NIH HHS T32 DE023526
6 · The paper itself

Abstract

Tooth agenesis is a common structural birth defect in humans that results from failure of morphogenesis during early tooth development. The homeobox transcription factor Msx1 and the canonical Wnt signaling pathway are essential for "bud to cap" morphogenesis and are causal factors for tooth agenesis. Our recent study suggested that Msx1 regulates Wnt signaling during early tooth development by suppressing the expression of

Indexed as

ToothWnt Signaling PathwayAnimalsBone Morphogenetic Protein 4Gene Expression Regulation, DevelopmentalMesodermMiceMorphogenesisMSX1 Transcription FactorOdontogenesisTooth GermBone Morphogenetic Protein 4Msx1 protein, mouseMSX1 Transcription Factorcell signalingcongenital abnormalitiesgeneticsgrowth factorshypodontiaodontogenesis

Identifiers

PMID35114852
PMCPMC9218501
OpenAlexW4210817997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.