Evidence map›Paper›PMID 35114353›Full record

Trial reportJournal of pain and symptom management2022

What's in the Sauce? The Specific Benefits of Palliative Care for Parkinson's Disease.

Meredith Bock, Maya Katz, Stefan Sillau, Kwame Adjepong, Kristine Yaffe, Roman Ayele, Zachary A Macchi, Steven Pantilat, Janis M Miyasaki, Benzi Kluger

Registry-linked trialOpen access · greenAbstract readPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of pain and symptom management, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02533921 (Does Outpatient Palliative Care Improve Patient-centered Outcomes in Parkinson's Disease?), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02533921 nacompletednot on this map

Does Outpatient Palliative Care Improve Patient-centered Outcomes in Parkinson's Disease?

TypeinterventionalSponsorUniversity of Colorado, DenverRan2015 to 2019Enrolled210ConditionsParkinson's DiseaseArmsInterdisciplinary outpatient palliative care, Standard of Care
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Meredith BockDepartment of Neurology, University of California, San Francisco, California, USA; San Francisco Veterans Affairs Medical Center, San Francisco, California, USA. Electronic address: Meredith.Bock@ucsf.edu.
Maya KatzDepartment of Neurology, Stanford University, California, USA.
Stefan SillauDepartment of Neurology, University of Colorado Anschutz Medical Campus, Colorado, USA.
Kwame AdjepongDepartment of Neurology, University of California, San Francisco, California, USA.
Kristine YaffeDepartment of Neurology, University of Colorado Anschutz Medical Campus, Colorado, USA; Department of Psychiatry, University of California, San Francisco, California, USA; Department of Epidemiology, University of California, San Francisco, California, USA.
Roman AyeleDepartment of Health Systems, Management and Policy, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Zachary A MacchiDepartment of Neurology, University of Colorado Anschutz Medical Campus, Colorado, USA.
Steven PantilatDepartment of Medicine, Division of Palliative Medicine at University of California, San Francisco California, USA.
Janis M MiyasakiDepartment of Medicine, Division of Neurology, University of Alberta, Edmonton, Canada.
Benzi KlugerDepartments of Neurology and Medicine, Division of Palliative Care, University of Rochester, Rochester, New Year, USA.
University of California, San Francisco · USUniversity of Colorado Anschutz Medical Campus · USSan Francisco VA Medical Center · USStanford University · USUniversity of Alberta · CAUniversity of Rochester · US

Funding

More than a Movement Disorder: Applying Palliative Care to Parkinson's Disease and Lewy Body DementiasR01NR016037 · NINR · UNIVERSITY OF ROCHESTER · PI KLUGER, BENZI M · 2016 to 2025
$6.5M
Multidisciplinary Research Training in Palliative CareT32AG044296 · NIA · UNIVERSITY OF COLORADO DENVER · PI STACY M FISCHER, JEAN S KUTNER · 2014 to 2026
$3.3M
Advancing Palliative Care for Older Adults Affected by Neurodegenerative Disease: Parkinsons disease, Alzheimers disease and Related DementiasK02AG062745 · NIA · UNIVERSITY OF ROCHESTER · PI KLUGER, BENZI M · 2020 to 2024
$711k
NIA NIH HHS K02 AG062745NIA NIH HHS T32 AG044296NINR NIH HHS R01 NR016037
6 · The paper itself

Abstract

contextIncreasing evidence demonstrates the benefits of palliative care among individuals with Parkinson's disease and related disorders (PDRD), but the critical components that contribute to therapeutic effects are not well understood.

objectivesTo determine the specific items most responsive to a palliative care intervention in PDRD and identify key correlates of improvement in patient and care partner outcomes.

methodsThe main trial was a pragmatic comparative effectiveness trial of outpatient integrated palliative care compared to standard care among participants with PDRD (NCT02533921), showing significantly higher patient QOL at six months and lower care partner burden at 12 months. We used longitudinal regression models to analyze changes in subdomains of patient QOL and care partner burden and Spearman correlations to evaluate key correlates of change scores in patient and care partner outcomes. We performed a secondary analysis of data from 210 patients and 175 care partners.

resultsCompared to controls, patients in the intervention reported greater improvement in perceptions of the "self as a whole" at six months (coeff = 0.22, P < 0.05) and care partners reported greater reduction in stress, anger, and loss of control at 12 months (coeff = -.40, -0.25, -0.31, P < 0.05). Positive change in numerous patient non-motor symptoms and grief correlated with improved patient QOL, reduced patient anxiety, and increased care partner spirituality. Alleviation of care partner anxiety and depression correlated with reduced care partner burden.

conclusionSpecific benefits of an integrated palliative approach in PDRD include improvement in patient holistic self-impressions, care partner self-efficacy, and non-motor symptoms.

Indexed as

Hospice and Palliative Care NursingParkinson DiseaseCaregiversHumansPalliative CareQuality of Lifeclinical trialpalliative careParkinson's disease

Identifiers

PMID35114353
PMCPMC9395211
OpenAlexW4210281715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.