ArticleCurrent biology : CB2022
Population temporal structure supplements the rate code during sensorimotor transformations.
Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 25 citations in OpenAlex.
- Similar Response Dynamics Represent Opposite Behaviors and Rewards in the Frontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque.eLife · 2026Article
- Drifting population dynamics with transient resets characterize sensorimotor transformation in the monkey superior colliculus.Communications biology · 2026Article
- Contribution of spike timing to the neural code: from fast to slow timescales.Biological cybernetics · 2026Review
- Simultaneous encoding of sensory features: the role of multiplexing and noise in tactile perception and neural representation.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Similar Dynamic Frontal Cortex Representations of Auditory Stimuli Cueing Opposite Actions and Rewards.bioRxiv : the preprint server for biology · 2025Article
- Superior colliculus peri-saccadic field potentials are dominated by a visual sensory preference for the upper visual field.iScience · 2025Article
- Scalable, flexible carbon fiber electrode thread arrays for three-dimensional probing of neurochemical activity in deep brain structures of rodents.Biosensors & bioelectronics · 2023Article
- Distinct context- and content-dependent population codes in superior colliculus during sensation and action.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Sensory tuning in neuronal movement commands.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A neural mechanism for terminating decisions.Neuron · 2023Article
- Rapid Input-Output Transformation between Local Field Potential and Spiking Activity during Sensation but not Action in the Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Scalable, flexible carbon fiber electrode thread arrays for three-dimensional spatial profiling of neurochemical activity in deep brain structures of rodents.bioRxiv : the preprint server for biology · 2023Article
- Ventral premotor cortex encodes task relevant features during eye and head movements.Scientific reports · 2022Article
- Superior colliculus saccade motor bursts do not dictate movement kinematics.Communications biology · 2022Article
- Article
- Sensorimotor transformation elicits systematic patterns of activity along the dorsoventral extent of the superior colliculus in the macaque monkey.Communications biology · 2019Article
- Instantaneous Midbrain Control of Saccade Velocity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
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Abstract
Sensorimotor transformations are mediated by premotor brain networks where individual neurons represent sensory, cognitive, and movement-related information. Such multiplexing poses a conundrum-how does a decoder know precisely when to initiate a movement if its inputs are active at times when a movement is not desired (e.g., in response to sensory stimulation)? Here, we propose a novel hypothesis: movement is triggered not only by an increase in firing rate but, critically, also by a reliable temporal pattern in the population response. Laminar recordings in the macaque superior colliculus (SC), a midbrain hub of orienting control, and pseudo-population analyses in SC and cortical frontal eye fields (FEFs) corroborated this hypothesis. Specifically, using a measure that captures the fidelity of the population code-here called temporal stability-we show that the temporal structure fluctuates during the visual response but becomes increasingly stable during the movement command. Importantly, we used spatiotemporally patterned microstimulation to causally test the contribution of population temporal stability in gating movement initiation and found that stable stimulation patterns were more likely to evoke a movement. Finally, a spiking neuron model was able to discriminate between stable and unstable input patterns, providing a putative biophysical mechanism for decoding temporal structure. These findings offer new insights into the long-standing debate on motor preparation and generation by situating the movement gating signal in temporal features of activity in shared neural substrates, and they highlight the importance of short-term population history in neuronal communication and behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.