Evidence map›Paper›PMID 35114045›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2022

Antibody-suppressor CXCR5

Jason M Zimmerer, Jing L Han, Chelsea M Peterson, Qiang Zeng, Bryce A Ringwald, Clarissa Cassol, Sachi Chaudhari, Madison Hart, Jessica Hemminger, Anjali Satoskar and 6 more

Open access · greenAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Jason M ZimmererDepartment of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-6091-327X
Jing L HanDepartment of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA.
Chelsea M PetersonDepartment of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA.
Qiang ZengCenter for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Bryce A RingwaldMedical Student Research Program, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Clarissa CassolDepartment of Pathology, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0001-7536-6806
Sachi ChaudhariDepartment of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-1883-1203
Madison HartDepartment of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA.
Jessica HemmingerDepartment of Pathology, The Ohio State University, Columbus, Ohio, USA.
Anjali SatoskarDepartment of Pathology, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-3332-0161
Mahmoud Abdel-RasoulCenter for Biostatistics, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-0653-0718
Jiao-Jing WangDepartment of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Robert T WarrenDepartment of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-8108-3965
Zheng J ZhangDepartment of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0001-6469-5778
Christopher K BreuerCenter for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0000-0003-0987-3898
Ginny L BumgardnerDepartment of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-3256-0200
The Ohio State University · USNationwide Children's Hospital · USNorthwestern University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
Advanced Research Training in Immunology for Surgery Trainees (ARTIST)T32AI106704 · NIAID · OHIO STATE UNIVERSITY · PI GINNY L BUMGARDNER, Jon R Wisler · 2014 to 2026
$3.5M
Investigating a Novel Cellular Therapy to Prevent and Treat Acute Antibody Mediated Kidney Transplant RejectionR01AI139913 · NIAID · OHIO STATE UNIVERSITY · PI BUMGARDNER, GINNY L · 2019 to 2023
$2.7M
Novel Mechanisms Regulating Posttransplant Humoral AlloimmunityR01AI083456 · NIAID · OHIO STATE UNIVERSITY · PI BUMGARDNER, GINNY L · 2011 to 2014
$1.5M
The molecular and spatial interactions between antibody suppressor CD8+ T cells and B cells that regulate alloantibody production after transplantF32AI161844 · NIAID · OHIO STATE UNIVERSITY · PI HAN, JING LIGHT · 2021 to 2022
$98k
NCATS NIH HHS UL1 TR002733NCATS NIH HHS UL1TR002733NCI NIH HHS P30 CA016058NIAID NIH HHS F32 AI161844NIAID NIH HHS R01 AI083456NIAID NIH HHS R01 AI139913NIAID NIH HHS T32 AI106704
6 · The paper itself

Abstract

CCR5 KO kidney transplant (KTx) recipients are extraordinarily high alloantibody producers and develop pathology that mimics human antibody-mediated rejection (AMR). C57BL/6 and CCR5 KO mice (H-2

Indexed as

Kidney TransplantationAnimalsCD8-Positive T-LymphocytesGraft RejectionImmunoglobulin GIsoantibodiesMiceMice, Inbred C57BLMice, KnockoutImmunoglobulin GIsoantibodiesalloantibodyantibody-mediated (ABMR)chemokine receptorschemokinesimmune regulationimmunobiologykidney transplantationnephrologyrejectionscienceT cell biologytranslational research

Identifiers

PMID35114045
PMCPMC9177711
OpenAlexW4212870481

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.