Evidence map›Paper›PMID 35113780›Full record

ArticleJournal of medical microbiology2022

Karmel Webb, Nur Masirah M Zain, Iain Stewart, Andrew Fogarty, Edward F Nash, Joanna L Whitehouse, Alan R Smyth, Andrew K Lilley, Alan Knox, Paul Williams and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medical microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. The redefined identity ofJournal of bacteriology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. The presence of cystic fibrosis-related diabetes modifies the sputum microbiome in cystic fibrosis disease.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Karmel WebbDivision of Epidemiology and Public Health, University of Nottingham, City Hospital Campus, Nottingham, UK.
Nur Masirah M ZainNottingham NIHR Biomedical Research Centre, Nottingham MRC Molecular Pathology Node, UK.
Iain StewartNottingham NIHR Biomedical Research Centre, Nottingham MRC Molecular Pathology Node, UK.
Andrew FogartyDivision of Epidemiology and Public Health, University of Nottingham, City Hospital Campus, Nottingham, UK.
Edward F NashWest Midlands Adult CF Centre, Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Joanna L WhitehouseWest Midlands Adult CF Centre, Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Alan R SmythNottingham NIHR Biomedical Research Centre, Nottingham MRC Molecular Pathology Node, UK.
Andrew K LilleyInstitute of Pharmaceutical Science, King's College London, UK.
Alan KnoxNottingham NIHR Biomedical Research Centre, Nottingham MRC Molecular Pathology Node, UK.
Paul WilliamsNational Biofilms Innovation Centre, Biodiscovery Institute, School of Life Sciences, University of Nottingham, Nottingham, UK.
Miguel CámaraNational Biofilms Innovation Centre, Biodiscovery Institute, School of Life Sciences, University of Nottingham, Nottingham, UK.
Kenneth BruceNottingham NIHR Biomedical Research Centre, Nottingham MRC Molecular Pathology Node, UK.
Helen L BarrNottingham NIHR Biomedical Research Centre, Nottingham MRC Molecular Pathology Node, UK.
University of Nottingham · GBKing's College London · GBUniversity Hospitals Birmingham NHS Foundation Trust · GBNottingham University Hospitals NHS Trust · GB

Funding

Medical Research Council G0801558Medical Research Council MR/N005953/1
6 · The paper itself

Abstract

Although anaerobic bacteria exist in abundance in cystic fibrosis (CF) airways, their role in disease progression is poorly understood. We hypothesized that the presence and relative abundance of the most prevalent, live, anaerobic bacteria in sputum of adults with CF were associated with adverse clinical outcomes. This is the first study to prospectively investigate viable anaerobic bacteria present in the sputum microbiota and their relationship with long-term outcomes in adults with CF. We performed 16S rRNA analysis using a viability quantitative PCR technique on sputum samples obtained from a prospective cohort of 70 adults with CF and collected clinical data over an 8 year follow-up period. We examined the associations of the ten most abundant obligate anaerobic bacteria present in the sputum with annual rate of FEV

Indexed as

Cystic FibrosisMicrobiotaPorphyromonasPrevotellaAdultHumansLungProspective StudiesRNA, Ribosomal, 16SSputumRNA, Ribosomal, 16Sanaerobic infectioncystic fibrosismicrobiology

Identifiers

PMID35113780
PMCPMC8941952
OpenAlexW4210616106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.