Evidence map›Paper›PMID 35113722›Full record

ArticleScience (New York, N.Y.)2022

Genome organization controls transcriptional dynamics during development.

Philippe J Batut, Xin Yang Bing, Zachary Sisco, João Raimundo, Michal Levo, Michael S Levine

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

157 citing papers in PubMed.

  1. Article
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  6. Transcription and Three-Dimensional Genome Organization: Cause, Consequence, or Coordination?BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
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  17. Article
  18. Maternal IntS11 primes embryonic totipotency by organizing early zygotic transcription initiation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  19. Article
  20. Article

97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Philippe J BatutLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0003-4250-0663
Xin Yang BingLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0001-6789-1918
Zachary SiscoLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
João RaimundoLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-8976-1898
Michal LevoLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-6647-8221
Michael S LevineLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0001-7629-0081

Funding

Visualization of gene activity in the Drosophila embryoR35GM118147 · NIGMS · PRINCETON UNIVERSITY · PI Michael Steven Levine · 2016 to 2026
$6.7M
NIGMS NIH HHS R35 GM118147
6 · The paper itself

Abstract

Past studies offer contradictory claims for the role of genome organization in the regulation of gene activity. Here, we show through high-resolution chromosome conformation analysis that the

Indexed as

Gene Expression Regulation, DevelopmentalGenes, HomeoboxGenome, InsectTranscription, GeneticAnimalsChromatinChromosomes, InsectDrosophilaEnhancer Elements, GeneticGenes, InsectPromoter Regions, GeneticRegulatory Sequences, Nucleic AcidSingle-Cell AnalysisChromatin

Identifiers

PMID35113722
PMCPMC10368186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.