Evidence map›Paper›PMID 35113710›Full record

ReviewScience (New York, N.Y.)2022

Per- and polyfluoroalkyl substances in the environment.

Marina G Evich, Mary J B Davis, James P McCord, Brad Acrey, Jill A Awkerman, Detlef R U Knappe, Andrew B Lindstrom, Thomas F Speth, Caroline Tebes-Stevens, Mark J Strynar and 4 more

Abstract readReview
In one paragraph

Review in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 392 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
392citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

392 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Environmental Endocrine-Disrupting Chemicals and Metabolic Dysfunction-Associated Steatotic Liver Disease.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Pooled it
  2. Article
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  8. Microbial ecology of shallow groundwater ecosystems.Nature reviews. Microbiology · 2026
    Review
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332 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marina G Evich *U.S. Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Environmental Measurement and Modeling, Athens, GA 30605, USA.ORCID 0000-0002-2386-0682
Mary J B Davis *U.S. Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Environmental Measurement and Modeling, Athens, GA 30605, USA.ORCID 0000-0001-6674-1678
James P McCord *EPA, ORD, Center for Environmental Measurement and Modeling, Durham, NC 27711, USA.ORCID 0000-0002-1780-4916
Brad AcreyU.S. Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Environmental Measurement and Modeling, Athens, GA 30605, USA.ORCID 0000-0001-5969-2222
Jill A AwkermanEPA, ORD, Center for Environmental Measurement and Modeling, Gulf Breeze, FL 32561, USA.ORCID 0000-0001-6692-5792
Detlef R U KnappeDepartment of Civil, Construction, and Environmental Engineering, North Carolina State University, Raleigh, NC 27695, USA.ORCID 0000-0003-1315-1791
Andrew B LindstromEPA, ORD, Center for Public Health and Environmental Assessment, Durham, NC 27711, USA.ORCID 0000-0001-7608-419X
Thomas F SpethEPA, ORD, Center for Environmental Solutions and Emergency Response, Cincinnati, OH 45268, USA.ORCID 0000-0002-6640-2737
Caroline Tebes-StevensU.S. Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Environmental Measurement and Modeling, Athens, GA 30605, USA.ORCID 0000-0001-7780-2691
Mark J StrynarEPA, ORD, Center for Environmental Measurement and Modeling, Durham, NC 27711, USA.ORCID 0000-0003-3472-7921
Zhanyun WangInstitute of Environmental Engineering, ETH Zürich, 8093 Zürich, Switzerland.ORCID 0000-0001-9914-7659
Eric J WeberU.S. Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Environmental Measurement and Modeling, Athens, GA 30605, USA.
W Matthew HendersonU.S. Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Environmental Measurement and Modeling, Athens, GA 30605, USA.ORCID 0000-0002-2800-8536
John W WashingtonU.S. Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Environmental Measurement and Modeling, Athens, GA 30605, USA.ORCID 0000-0001-9952-600X

Funding

Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - RENEWALP42ES027706 · NIEHS · UNIVERSITY OF RHODE ISLAND · PI Harrison Dekker · 2017 to 2026
$18.9M
Uncovering the Mechanisms of PFAS-induced ImmunotoxicityP42ES031009 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI PLANCHART, ANTONIO J. · 2020 to 2024
$9.3M
Intramural EPA EPA999999NIEHS NIH HHS P42 ES027706NIEHS NIH HHS P42 ES031009
6 · The paper itself

Abstract

Over the past several years, the term PFAS (per- and polyfluoroalkyl substances) has grown to be emblematic of environmental contamination, garnering public, scientific, and regulatory concern. PFAS are synthesized by two processes, direct fluorination (e.g., electrochemical fluorination) and oligomerization (e.g., fluorotelomerization). More than a megatonne of PFAS is produced yearly, and thousands of PFAS wind up in end-use products. Atmospheric and aqueous fugitive releases during manufacturing, use, and disposal have resulted in the global distribution of these compounds. Volatile PFAS facilitate long-range transport, commonly followed by complex transformation schemes to recalcitrant terminal PFAS, which do not degrade under environmental conditions and thus migrate through the environment and accumulate in biota through multiple pathways. Efforts to remediate PFAS-contaminated matrices still are in their infancy, with much current research targeting drinking water.

Indexed as

Environmental PollutantsFluorocarbon PolymersFluorocarbonsAnimalsBiodegradation, EnvironmentalDrinking WaterEnvironmental ExposureEnvironmental Restoration and RemediationHalogenationHumansWater Pollution, ChemicalDrinking WaterEnvironmental PollutantsFluorocarbon PolymersFluorocarbons

Identifiers

PMID35113710
PMCPMC8902460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.