Evidence map›Paper›PMID 35113661›Full record

ArticleCirculation research2022

Research Goes Red: Early Experience With a Participant-Centric Registry.

Susan C Gilchrist, Jennifer L Hall, Abha Khandelwal, Bertha Hidalgo, Brooke Aggarwal, Claire Kinzy, Pratheek Mallya, Katie Conners, Laura M Stevens, Heather M Alger and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 2 countries.

Susan C GilchristDepartments of Clinical Cancer Prevention and Cardiology, The University of Texas MD Anderson Cancer Center, Houston (S.C.G.).
Jennifer L HallAmerican Heart Association, Dallas, TX (J.L.H., C.K., P.M., L.M.S., H.M.A., M.J.).ORCID 0000-0002-5103-5399
Abha KhandelwalDivision of Cardiology, Stanford University School of Medicine, Palo Alto, CA (A.K.).
Bertha HidalgoDivision of Cardiology, Stanford University School of Medicine, Palo Alto, CA (A.K.).
Brooke AggarwalDivision of Cardiology, Stanford University School of Medicine, Palo Alto, CA (A.K.).
Claire KinzyAmerican Heart Association, Dallas, TX (J.L.H., C.K., P.M., L.M.S., H.M.A., M.J.).
Pratheek MallyaAmerican Heart Association, Dallas, TX (J.L.H., C.K., P.M., L.M.S., H.M.A., M.J.).
Katie ConnersEpidemiology and Community Health Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (K.C., V.L.R.).
Laura M StevensAmerican Heart Association, Dallas, TX (J.L.H., C.K., P.M., L.M.S., H.M.A., M.J.).ORCID 0000-0002-1770-9556
Heather M AlgerAmerican Heart Association, Dallas, TX (J.L.H., C.K., P.M., L.M.S., H.M.A., M.J.).ORCID 0000-0003-1795-9675
Laxmi MehtaDivision of Cardiology, Ohio State University Wexner Medical Center, Columbus (L.M.).ORCID 0000-0003-3493-1930
Laura WexlerDepartment of Internal Medicine, University of Cincinnati, OH (L.W.).
Jessica L MegaVerily (J.L.M.).
Adrian HernandezDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.H.).ORCID 0000-0003-3387-9616
Sharonne N HayesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (S.N.H.).ORCID 0000-0003-3129-362X
Jennifer H MieresDepartment of Cardiology, Zucker School of Medicine at Hofstra/Northwell Health, Hempstead, NY (J.H.M.).
Mariell JessupAmerican Heart Association, Dallas, TX (J.L.H., C.K., P.M., L.M.S., H.M.A., M.J.).ORCID 0000-0002-3010-0112
Veronique L RogerEpidemiology and Community Health Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (K.C., V.L.R.).ORCID 0000-0002-9347-7865
American Heart Association · USPalo Alto University · USNational Heart Lung and Blood Institute · USDuke University · USHofstra University · USMayo Clinic · USThe Ohio State University Wexner Medical Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of Cincinnati · USVerizon (United States) · US

Funding

The AnVIL Data Ecosystem DACReS SupplementU24HG010262 · NHGRI · BROAD INSTITUTE, INC. · PI Robert J Carroll, Jonathan Lawson · 2018 to 2026
$40.5M
NHGRI NIH HHS U24 HG010262
6 · The paper itself

Abstract

rationaleCardiovascular disease remains the leading cause of death in women. To address its determinants including persisting cardiovascular risk factors amplified by sex and race inequities, novel personalized approaches are needed grounded in the engagement of participants in research and prevention.

objectiveTo report on a participant-centric and personalized dynamic registry designed to address persistent gaps in understanding and managing cardiovascular disease in women. METHODS AND

resultsThe American Heart Association and Verily launched the Research Goes Red registry (RGR) in 2019, as an online research platform available to consenting individuals over the age of 18 years in the United States. RGR aims to bring participants and researchers together to expand knowledge by collecting data and providing an open-source longitudinal dynamic registry for conducting research studies. As of July 2021, 15 350 individuals have engaged with RGR. Mean age of participants was 48.0 48.0±0.2 years with a majority identifying as female and either non-Hispanic White (75.7%) or Black (10.5%). In addition to 6 targeted health surveys, RGR has deployed 2 American Heart Association-sponsored prospective clinical studies based on participants' areas of interest. The first study focuses on perimenopausal weight gain, developed in response to a health concerns survey. The second study is designed to test the use of social media campaigns to increase awareness and participation in cardiovascular disease research among underrepresented millennial women.

conclusionsRGR is a novel online participant-centric platform that has successfully engaged women and provided critical data on women's heart health to guide research. Priorities for the growth of RGR are centered on increasing reach and diversity of participants, and engaging researchers to work within their communities to leverage the platform to address knowledge gaps and improve women's health.

Indexed as

RegistriesAdolescentAdultAgedCardiovascular DiseasesFemaleHumansMiddle AgedPatient-Centered CarePatient ParticipationSocial Mediacardiovascular diseasesdeathhealthknowledgerisk factors

Identifiers

PMID35113661
PMCPMC10505520
OpenAlexW4210262318

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.