Evidence map›Paper›PMID 35113613›Full record

Trial reportPsychology and aging2022

Good clinical practice improves rigor and transparency: Lessons from the ACTIVE trial.

Brad P Taylor, George W Rebok, Michael Marsiske

Open access · hybridAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Psychology and aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Brad P TaylorDepartment of Clinical and Health Psychology, University of Florida.ORCID 0000-0002-9827-9630
George W RebokDepartment of Mental Health, Johns Hopkins University.
Michael MarsiskeDepartment of Clinical and Health Psychology, University of Florida.
University of Florida Health · USJohns Hopkins University · US

Funding

Research Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer's DiseaseT32AG020499 · NIA · UNIVERSITY OF FLORIDA · PI MARSISKE, MICHAEL, SMITH, GLENN E. · 2003 to 2024
$3.7M
TRIAL OF A COGNITIVE INTERVENTION FOR OLDER ADULTSU01AG014260 · NIA · JOHNS HOPKINS UNIVERSITY · PI REBOK, GEORGE W. · 1996 to 2010
$3.4M
COGNITIVE APPROACH TO MAINTAINING SELF CARE INVOLVEMENTU01NR004507 · NINR · HEBREW REHABILITATION CENTER FOR AGED · PI MORRIS, JOHN N. · 1996 to 2010
$3.1M
Long-term Effects of ACTIVE Cognitive Training on Everyday Functioning and Dementia-related Outcomes: Association of Race and Social Determinants of HealthR01AG056486 · NIA · UNIVERSITY OF WASHINGTON · PI REBOK, GEORGE W., WILLIS, SHERRY L · 2017 to 2020
$3.1M
TRIAL OF A COGNITIVE INTERVENTION FOR OLDER ADULTS--CCU01AG014282 · NIA · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI TENNSTEDT, SHARON L · 1996 to 2010
$3.0M
MAINTENANCE AND ENHANCEMENT OF COGNITIVE ADLSU01NR004508 · NINR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI UNVERZAGT, FREDERICK W. · 1996 to 2010
$2.8M
FLUID REASONING TRAINING FOR URBAN ELDERSU01AG014276 · NIA · WAYNE STATE UNIVERSITY · PI MARSISKE, MICHAEL · 1996 to 2010
$2.7M
FLUID ABILITY TRAINING AMONG ELDERLYU01AG014263 · NIA · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI WILLIS, SHERRY L · 1996 to 2010
$2.3M
COGNITIVE TRAINING &EVERYDAY COMPETENCE IN THE ELDERLYU01AG014289 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BALL, KARLENE K · 1996 to 2010
$2.3M
NIA NIH HHS R01 AG056486NIA NIH HHS T32 AG020499NIA NIH HHS U01 AG014260NIA NIH HHS U01 AG014263NIA NIH HHS U01 AG014276NIA NIH HHS U01 AG014282NIA NIH HHS U01 AG014289NINR NIH HHS U01 NR004507NINR NIH HHS U01 NR004508
6 · The paper itself

Abstract

Clinical trials are governed by principles of good clinical practice (GCP), which can strengthen the achievement of rigor, reproducibility, and transparency in scientific research. Rigor, reproducibility, and transparency are key for producing findings with greater certainty. Clinical trials are closely supervised, often by a clinical trial coordinating center, data safety and monitoring board, and a funding agency, with policies that are a manifestation of GCP and support rigor, reproducibility, and transparency. The multisite Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study is an example clinical trial of relevance to a psychology and aging audience that utilized many protocols that can be applied to single-laboratory designs, including a manualized protocol with accompanying scientific rationale, predefined analysis plans, standardization of procedures across field sites, assurance of competence of study staff in study procedures, transparent coding/entry/transmittal of data, regular quality assurance, and open publication of data. Despite substantial resource discrepancies between the two, single-laboratory studies can model the GCP principles utilized in large clinical trials to provide an excellent foundation for rigor, reproducibility, and transparency. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Indexed as

Research DesignAgedHumansReproducibility of Results

Identifiers

PMID35113613
PMCPMC10022634
OpenAlexW4212940012

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.