ArticleJournal of the American Geriatrics Society2022
The relationship between multimorbidity, obesity and functional impairment in older adults.
Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- EffectS of Lifestyle Interventions in Older PEople With Obesity (Effective SLOPE): a Systematic Review With Network Meta-Analyses.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- About half of older adults have two or more chronic conditions at the same time: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- The prevalence of disability in older adults with multimorbidity: a meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Caloric restriction and time-restricted eating in older adults with overweight or obesity: The Health, Aging, and Later-Life Outcomes Pilot Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- Clinical and Economic Burden of Obesity and Cardiovascular Disease Among Medicare Fee-For-Service Beneficiaries.Diabetes, obesity & metabolism · 2026Article
- Clinical obesity phenotypes among older adults: prevalence, determinants, and morbidity burden from the Longitudinal Ageing Study in India.International journal of obesity (2005) · 2026Article
- Risk of protein intake deficiency during treatment with GLP-1 and GIP/GLP-1 receptor agonists: considerations for secondary sarcopenia.Advances in therapy · 2026Review
- Multivariable Associations of Anthropometric and Psychosocial Markers with an Elevated Abdominal Volume Index Among University Students: A Sex- and Academic Program-Stratified Analysis.Healthcare (Basel, Switzerland) · 2026Article
- Associations Between Social Risks and Obesity in High-risk Veterans.Journal of general internal medicine · 2026Article
- The validity and reliability of the six-minute pegboard and ring test for assessing upper extremity exercise capacity in individuals with overweight and obesity: a cross-sectional study.BMC sports science, medicine & rehabilitation · 2026Article
- Sarcopenia, Obesity, and Sarcopenic Obesity in Relation to Functional Limitations in Older Adults.Journal of clinical medicine · 2026Article
- Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan.Journal of endocrinological investigation · 2025Review
- A geriatrician's approach to managing the complex older adult with obesity.Obesity (Silver Spring, Md.) · 2025Review
- Poor muscle quality: A hidden and detrimental health condition in obesity.Reviews in endocrine & metabolic disorders · 2025Review
- Epidemiology Landscape and Impact of Overweight and Obesity in Adults: Multi-country Results from the IMPACT-O Study.Advances in therapy · 2025Article
- Exploring population and sex-specific disease trajectories for multimorbidities among individuals with overweight or obesity: A retrospective cohort study in UK biobank.Diabetes, obesity & metabolism · 2025Article
- Obesity and Transition to Assisted Living Services in Older Adults: An Analysis From the National Health and Aging Trends Study.Journal of the American Geriatrics Society · 2025Article
- Article
- Lifestyle Medicine for Obesity in the Era of Highly Effective Anti-Obesity Treatment.Nutrients · 2025Review
- Frailty and depressive symptoms in relation to cardiovascular disease risk in middle-aged and older adults.Nature communications · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundDeclining mortality rates and an aging population have contributed to increasing rates of multimorbidity (MM) in the United States. MM is strongly associated with a decline in physical function. Obesity is an important risk factor for the development of MM, and its prevalence continues to rise. Our study aimed to evaluate the associations between obesity, MM, and rates of functional limitations in older adults.
methodsWe analyzed body mass index (BMI) and self-reported comorbidity data from 7261 individuals aged ≥60 years from the National Health and Nutrition Examination Surveys 2005-2014. Weight status was defined based on standard BMI categories. MM was defined as 2 or more comorbidities, while functional limitations were self-reported. Adjusted logistic regression quantified the association between standard BMI categories and MM. We also examined the difference in the prevalence of limitations between those with and without MM.
resultsThe overall proportion of individuals with concomitant MM and obesity was 27.0%. Compared to a normal BMI, older adults with obesity had higher odds of MM (Prevalence odds ratio 1.79, 95% CI 1.49, 2.12). Overall, 67.5% of patients with MM also reported a functional limitation, with rates of functional limitation increasing with increasing BMI. When evaluating functional limitations in those with MM by BMI class, 90% of patients classified as severely obese (BMI ≥40 kg/m
conclusionsCompared to normal weight status, obesity is associated with an increased burden of MM and functional limitation among older adults. Our results underscore the importance of identifying and addressing obesity, MM, and functional limitation patterns and the need for evidence-based interventions that address all three conditions in this population.
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