Evidence map›Paper›PMID 35113386›Full record

SynthesisSports medicine (Auckland, N.Z.)2022

Effects of Endurance Training on Motor Signs of Parkinson's Disease: A Systematic Review and Meta-Analysis.

Filipe Oliveira de Almeida, Vagner Santana, Daniel M Corcos, Carlos Ugrinowitsch, Carla Silva-Batista

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Sports medicine (Auckland, N.Z.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Frontiers in sports and active living · 2025
    Article
  11. Review
  12. Update: Protective and risk factors for Parkinson disease.Parkinsonism & related disorders · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Advice to People with Parkinson's in My Clinic: Exercise.Journal of Parkinson's disease · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Filipe Oliveira de Almeida *Exercise Neuroscience Research Group, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-0014-6280
Vagner Santana *Exercise Neuroscience Research Group, University of São Paulo, São Paulo, Brazil.
Daniel M CorcosDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-7440-6458
Carlos UgrinowitschLaboratory of Adaptations To Strength Training, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-8547-419X
Carla Silva-BatistaExercise Neuroscience Research Group, University of São Paulo, São Paulo, Brazil. csilvabatista@usp.br.ORCID http://orcid.org/0000-0003-0244-6535

Funding

NIH HHS U01NS11385
6 · The paper itself

Abstract

backgroundEvidence has demonstrated that endurance training (ET) reduces the motor signs of Parkinson's disease (PD). However, there has not been a comprehensive meta-analysis of studies to date.

objectiveThe aim of this study was to compare the effect of ET versus nonactive and active control conditions on motor signs as assessed by either the Unified Parkinson's Disease Rating Scale part III (UPDRS-III) or Movement Disorder Society-UPDRS-III (MDS-UPDRS-III).

methodsA random-effect meta-analysis model using standardized mean differences (Hedges' g) determined treatment effects. Moderators (e.g., combined endurance and physical therapy training [CEPTT]) and meta-regressors (e.g., number of sessions) were used for sub-analyses. Methodological quality was assessed by the Physiotherapy Evidence Database.

resultsTwenty-seven randomized controlled trials (RCTs) met inclusion criteria (1152 participants). ET is effective in decreasing UPDRS-III scores when compared with nonactive and active control conditions (g =  - 0.68 and g =  - 0.33, respectively). This decrease was greater (within- and between-groups average of - 8.0 and - 6.8 point reduction on UPDRS-III scores, respectively) than the moderate range of clinically important changes to UPDRS-III scores (- 4.5 to - 6.7 points) suggested for PD. Although considerable heterogeneity was observed between RCTs (I

conclusionsET is effective in decreasing UPDRS-III scores. Questions remain about the dose-response relationship between ET and reduction in motor signs.

Indexed as

Endurance TrainingParkinson DiseaseGaitHumansMental Status and Dementia TestsPhysical Therapy Modalities

Identifiers

PMID35113386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.