ArticleBrain structure & function2022
Enhanced habit formation in Tourette patients explained by shortcut modulation in a hierarchical cortico-basal ganglia model.
Article in Brain structure & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Pallidal Deep Brain Stimulation Enhances Habitual Behavior in a Neuro-Computational Basal Ganglia Model During a Reward Reversal Learning Task.The European journal of neuroscience · 2025Article
- When the interoceptive and conceptual clash: The case of oppositional phenomenal self-modelling in Tourette syndrome.Cognitive, affective & behavioral neuroscience · 2024Review
- Resting network architecture of theta oscillations reflects hyper-learning of sensorimotor information in Gilles de la Tourette syndrome.Brain communications · 2024Article
- The Dysfunctional Mechanisms Throwing Tics: Structural and Functional Changes in Tourette Syndrome.Behavioral sciences (Basel, Switzerland) · 2023Review
- The contribution of the basal ganglia and cerebellum to motor learning: A neuro-computational approach.PLoS computational biology · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Devaluation protocols reveal that Tourette patients show an increased propensity to habitual behaviors as they continue to respond to devalued outcomes in a cognitive stimulus-response-outcome association task. We use a neuro-computational model of hierarchically organized cortico-basal ganglia-thalamo-cortical loops to shed more light on habit formation and its alteration in Tourette patients. In our model, habitual behavior emerges from cortico-thalamic shortcut connections, where enhanced habit formation can be linked to faster plasticity in the shortcut or to a stronger feedback from the shortcut to the basal ganglia. We explore two major hypotheses of Tourette pathophysiology-local striatal disinhibition and increased dopaminergic modulation of striatal medium spiny neurons-as causes for altered shortcut activation. Both model changes altered shortcut functioning and resulted in higher rates of responses towards devalued outcomes, similar to what is observed in Tourette patients. We recommend future experimental neuroscientific studies to locate shortcuts between cortico-basal ganglia-thalamo-cortical loops in the human brain and study their potential role in health and disease.
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