Evidence map›Paper›PMID 35113221›Full record

ArticleParasitology research2022

Anti-Trichomonas vaginalis activity and chemical analysis of metabolites produced by marine-associated fungi.

Franciane Rios Senger, Rodrigo Campos-Silva, Melissa Fontes Landell, Denise Brentan Silva, Camila Braz Menezes, Graziela Vargas Rigo, Laura Nunes Silva, Danielle Silva Trentin, Alexandre José Macedo, Tiana Tasca

Abstract read
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In one paragraph

Article in Parasitology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Franciane Rios SengerFaculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Av. Ipiranga 2752, Porto Alegre, RS, 90610-000, Brazil.
Rodrigo Campos-SilvaFaculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Av. Ipiranga 2752, Porto Alegre, RS, 90610-000, Brazil.
Melissa Fontes LandellInstituto de Ciências Biológicas E da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brazil.
Denise Brentan SilvaLaboratório de Produtos Naturais E Espectrometria de Massas (LaPNEM), Faculdade de Ciências Farmacêuticas, Alimentos E Nutrição (FACFAN), Universidade Federal de Mato Grosso Do Sul (UFMS), Campo Grande, MS, Brazil.
Camila Braz MenezesFaculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Av. Ipiranga 2752, Porto Alegre, RS, 90610-000, Brazil.
Graziela Vargas RigoFaculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Av. Ipiranga 2752, Porto Alegre, RS, 90610-000, Brazil.
Laura Nunes SilvaFaculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Av. Ipiranga 2752, Porto Alegre, RS, 90610-000, Brazil.
Danielle Silva TrentinDepartamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
Alexandre José MacedoFaculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Av. Ipiranga 2752, Porto Alegre, RS, 90610-000, Brazil.
Tiana TascaFaculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Av. Ipiranga 2752, Porto Alegre, RS, 90610-000, Brazil. tiana.tasca@ufrgs.br.ORCID http://orcid.org/0000-0002-8334-5105
Universidade Federal do Rio Grande do Sul · BRUniversidade Federal de Alagoas · BRUniversidade Federal de Ciências da Saúde de Porto Alegre · BRUniversidade Federal de Mato Grosso do Sul · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 309054/2016-8Conselho Nacional de Desenvolvimento Científico e Tecnológico 312292/2017-1Conselho Nacional de Desenvolvimento Científico e Tecnológico 408578/2013-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 408718/2013-7Conselho Nacional de Desenvolvimento Científico e Tecnológico 443150/2014-1Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 16/2551-0000244-4
6 · The paper itself

Abstract

Trichomoniasis is the most common non-viral sexually transmitted infection worldwide and it may have serious consequences, especially for women. Currently, 5-nitroimidazole drugs are the treatment of choice for trichomoniasis, although presenting adverse effects and reported cases of drug resistance. Metabolites isolated from marine fungi have attracted considerable attention due to their unique chemical structures with diverse biological activities, including antiprotozoal activity. In this study, we showed the anti-Trichomonas vaginalis activity of fractions obtained from marine fungi and the chemical composition of the most active fraction was determined. Ethyl acetate fractions of the fungus Aspergillus niger (EAE03) and Trichoderma harzianum/Hypocrea lixii complex (EAE09) were active against T. vaginalis. These samples, EAE03 and EAE09, were also effective against the fresh clinical isolate metronidazole-resistant TV-LACM2R, presenting MIC values of 2.0 mg/mL and 1.0 mg/mL, respectively. The same MIC values were found against ATCC 30,236 T. vaginalis isolate. In vitro cytotoxicity revealed only the fraction named EAE03 with no cytotoxic effect; however, the active fractions did not promote a significant hemolytic effect after 1-h incubation. Already, the in vivo toxicity evaluation using Galleria mellonella larvae demonstrated that none of the tested samples caused a reduction in animal survival. The fraction EAE03 was followed for purification steps and analyzed by LC-DAD-MS. Eleven compounds were annotated, including butyrolactone, butanolide, and atromentin. Overall, the range of activities reported confirms the potential of marine fungi to produce bioactive molecules.

Indexed as

Antiprotozoal AgentsTrichomonas InfectionsTrichomonas vaginalisAnimalsFemaleFungiHumansMetronidazoleAntiprotozoal AgentsMetronidazoleMarine fungiMetabolitesTrichomonas vaginalisTrichomoniasis

Identifiers

PMID35113221
OpenAlexW4210674028

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.