SynthesisInternational orthopaedics2022
A meta-analysis comparing the short- and mid- to long-term outcomes of artificial cervical disc replacement(ACDR) with anterior cervical discectomy and fusion (ACDF) for the treatment of cervical degenerative disc disease.
Synthesis in International orthopaedics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Cervical disc replacement versus anterior cervical discectomy and fusion using stand-alone cage for degenerative cervical spondylosis: a systematic review and meta-analysis based on randomized controlled trials.Neurosurgical review · 2025Pooled it
- Global trends in cervical spondylosis research: a bibliometric analysis based on the Web of Science.Frontiers in neurology · 2025Pooled it
- Effect of Keeping Caspar Retractor During Prestige LP Cervical Disc Implantation on Intra- and Postoperative Outcomes.Orthopaedic surgery · 2026Article
- Cervical disc arthroplasty versus minimally invasive posterior cervical procedures as motion preserving surgeries for cervical radiculopathy: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Long-Term Comparison of Single-Level Bryan and ProDisc-C Cervical Disc Arthroplasty: A Minimum 10-year Follow-Up of Clinical and Radiographic Outcomes.Global spine journal · 2026Article
- Different Center of Rotation Trajectories after Cervical Hybrid Surgery: A Minimum 7-Year Retrospective Comparison of Bryan and Mobi-C Prostheses.Global spine journal · 2026Article
- Multimodal ultrasonography for the prospective evaluation of soft-tissue changes after anterior cervical discectomy and fusion.Journal of orthopaedic surgery and research · 2026Observational
- Comparative Outcomes of Anterior Cervical Discectomy and Fusion Vs Hybrid Surgery in Multilevel Cervical Degenerative Disc Disease: A Systematic Review and Meta-analysis.International journal of spine surgery · 2026Article
- Article
- Comparison of 10-year follow-up result of hybrid surgery and anterior cervical discectomy and fusion for the treatment of contiguous three-level cervical degenerative disc diseases: risk factors for heterotopic ossification.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Reoperation Strategy for Failure of Cervical Disc Arthroplasty at Index and Adjacent Levels.Journal of clinical medicine · 2025Review
- Influence of the deviated center of rotation on facet joint degeneration after cervical disc replacement - an in vivo study with a minimum of 10-year follow-up.BMC surgery · 2024Article
- Review
- Artificial intelligence in predicting postoperative heterotopic ossification following anterior cervical disc replacement.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- A comparative study of the effect of facet tropism on the index-level kinematics and biomechanics after artificial cervical disc replacement (ACDR) with Prestige LP, Prodisc-C vivo, and Mobi-C: a finite element study.Journal of orthopaedic surgery and research · 2024Article
- Cervical Disc Arthroplasty (CDA) versus Anterior Cervical Discectomy and Fusion (ACDF) for Two-Level Cervical Disc Degenerative Disease: An Updated Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Changes in the centre of rotation and the anterior bone loss of the vertebral body in Mobi-C artificial disc replacement segments after cervical hybrid surgery: a retrospective study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Adjacent segment degeneration after single- and double-level cervical total disc replacement: a cohort with an over 12-year follow-up.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Mechanical properties of an elastically deformable cervical spine implant.Journal of orthopaedic surgery and research · 2023Article
- Current Indications for Spinal Endoscopic Surgery and Potential for Future Expansion.Neurospine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeAnterior cervical discectomy and fusion (ACDF) surgery is commonly performed to treat cervical degenerative disc disease (CDDD). The lost of range of motion (ROM) is also found after ACDF, which contributes to degenerate in adjacent segment disease (ASD). Artificial cervical disc replacement (ACDR), an alternative to ACDF, is developed to preserve the ROM and reduce ASD. This article aims to compare the outcomes between ACDR and ACDF in the short-, mid-, and long-term.
methodsDatabases including Cochrane, Embase, PubMed, and Web of Science were searched. Only RCTs were included in this meta-analysis, and the search strategy followed the requirements of the Cochrane Handbook. The strength of evidence was assessed using GRADE. Two reviewers independently assessed the methodological quality of each included study and extracted the relevant data.
resultsThirty prospective RCTs were included. Prolonged operative duration, better overall success, neurological success, and NDI success rates were found in ACDR group in all follow-up periods, with lower dysphagia/dysphonia during short-term follow-up. Moreover, a lower ASD was found in ACDR group during long-term follow-up and overall analysis, with lower reoperation rates in all follow-up periods. Comparable length of hospital stay and blood loss were found in both groups. Moreover, ASD was similar in short- and mid-term follow-ups, while dysphagia/dysphonia incidence was similar in mid- and long-term follow-ups. The incidence of implant events was comparable in all follow-up periods (p > 0.05).
conclusionsACDR is as effective as ACDF and superior for some success rates. Disc replacement can reduce the risk of dysphagia/dysphonia, ASD, and re-operation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.