Evidence map›Paper›PMID 35112931›Full record

Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2022

No effect of acute tetrahydrobiopterin (BH

Angela V Bisconti, Ryan S Garten, Ryan M Broxterman, Catherine L Jarrett, Soung Hun Park, Katherine L Shields, Heather L Clifton, Stephen M Ratchford, Van Reese, Jia Zhao and 2 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Angela V BiscontiGeriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah.ORCID 0000-0003-0156-2593
Ryan S GartenGeriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah.ORCID 0000-0002-8939-6093
Ryan M BroxtermanGeriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah.ORCID 0000-0002-7388-2214
Catherine L JarrettGeriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah.ORCID 0000-0001-5131-7858
Soung Hun ParkDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah.
Katherine L ShieldsDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah.ORCID 0000-0001-5399-7332
Heather L CliftonGeriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah.
Stephen M RatchfordGeriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah.ORCID 0000-0002-6300-7600
Van ReeseDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah.
Jia ZhaoDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah.
D Walter WrayDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah.
Russell S RichardsonDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah.
University of Utah · USVirginia Commonwealth University · US

Funding

Cardiovasomobility Research Training ProgramT32HL139451 · NHLBI · UNIVERSITY OF UTAH · PI SUPIANO, MARK A, WRAY, D. WALTER · 2018 to 2022
$1.4M
Novel Approaches for Improving Vascular Function in Veterans with HFpEFI01CX002152 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI D. Walter Wray · 2021 to 2026
–
CSRD VA I01 CX002152NHLBI NIH HHS T32 HL139451NIH HHS T32HL139451VA E6910-R; E1697-R; E3207-R; E9275-L; E1572; I01RX001311; I01CX002152
6 · The paper itself

Abstract

As a deficiency in tetrahydrobiopterin (BH

Indexed as

Endothelium, VascularNitric Oxide Synthase Type IIIAgedBiopterinsDietary SupplementsHumansOxidative StressBiopterinsNitric Oxide Synthase Type IIIsapropterinagingBH2FMDshear ratevascular function

Identifiers

PMID35112931
PMCPMC8917921
OpenAlexW4210331525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.