ArticleEnvironmental health perspectives2022
Effect of Atmospheric Aging on Soot Particle Toxicity in Lung Cell Models at the Air-Liquid Interface: Differential Toxicological Impacts of Biogenic and Anthropogenic Secondary Organic Aerosols (SOAs).
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Article in Environmental health perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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25 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Toxicological Effects of Air Pollutants on Human Airway Cell Models Using Air-liquid Interface Systems: A Systematic Review.Current environmental health reports · 2025Pooled it
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- Next-generation high-throughput in vitro exposure system for early hazard ranking and comparative assessment of cigarette smoke and heated tobacco aerosols.Environmental sciences Europe · 2025Article
- An Online Measurement Approach to Monitor the Deposition of Diesel Exhaust Particles on Lung Cells In Vitro.Environmental science & technology · 2025Article
- The efficiency of EURO 6d car particulate filters is compromised by atmospheric aging: In vitro toxicity of gasoline car exhaust.Science advances · 2025Article
- Short-lived reactive components substantially contribute to particulate matter oxidative potential.Science advances · 2025Article
- The effects of photochemical aging and interactions with secondary organic aerosols on cellular toxicity of combustion particles.Journal of aerosol science · 2025Article
- The chemical composition of secondary organic aerosols regulates transcriptomic and metabolomic signaling in an epithelial-endothelial in vitro coculture.Particle and fibre toxicology · 2024Article
- The Oxidative Potential of Airborne Particulate Matter Research Trends, Challenges, and Future Perspectives-Insights from a Bibliometric Analysis and Scoping Review.Antioxidants (Basel, Switzerland) · 2024Article
- Combining analytical techniques to assess the translocation of diesel particles across an alveolar tissue barrier in vitro.Particle and fibre toxicology · 2024Article
- Human Airway Organoids and Multimodal Imaging-Based Toxicity Evaluation of 1-Nitropyrene.Environmental science & technology · 2024Article
- Chemical Fingerprinting of Biomass Burning Organic Aerosols from Sugar Cane Combustion: Complementary Findings from Field and Laboratory Studies.ACS earth & space chemistry · 2024Article
- [Metformin ameliorates PM2.5-induced functional impairment of placental trophoblasts by inhibiting ferroptosis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Particulate matter composition drives differential molecular and morphological responses in lung epithelial cells.PNAS nexus · 2024Article
- The Cytotoxic Effects of Fine Particulate Matter (PMToxics · 2023Article
- PMCell biology and toxicology · 2023Article
- Chemical and Cellular Formation of Reactive Oxygen Species from Secondary Organic Aerosols in Epithelial Lining Fluid.Research report (Health Effects Institute) · 2023Article
- Exposure to urban nanoparticles at low PM[Formula: see text] concentrations as a source of oxidative stress and inflammation.Scientific reports · 2023Article
- Oxidized and Unsaturated: Key Organic Aerosol Traits Associated with Cellular Reactive Oxygen Species Production in the Southeastern United States.Environmental science & technology · 2023Article
- Iron and Copper Alter the Oxidative Potential of Secondary Organic Aerosol: Insights from Online Measurements and Model Development.Environmental science & technology · 2023Article
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Authors and funding
43 authors at 8 institutions in 5 countries.
Svenja OfferJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Elena HartnerJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Sebastiano Di BucchianicoJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-6396-892X
Christoph BisigJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0001-9981-1409
Stefanie BauerJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Jana PantzkeJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0001-5420-8905
Elias J ZimmermannJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-8766-180X
Xin CaoJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Stefanie BinderJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Evelyn KuhnJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Anja HuberJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Seongho JeongJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0001-8057-7827
Uwe KäferJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-4016-0661
Patrick MartensJMSC at Analytical Chemistry, Institute of Chemistry, University of Rostock, Rostock, Germany.ORCID 0000-0002-5719-872X
Arunas MesceriakovasDepartment of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-3257-5293
Jan BendlJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0003-2322-5483
Ramona BrejchaJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Angela BuchholzDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-7119-1452
Daniella GatDepartment of Earth and Planetary Sciences, Faculty of Chemistry, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-0595-4626
Thorsten HohausInstitute of Energy and Climate Research, Troposphere, Forschungszentrum Jülich GmbH, Jülich, Germany.ORCID 0000-0001-5722-6244
Narges RastakJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Gert JakobiJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Markus KalbererDepartment of Environmental Sciences, University of Basel, Basel, Switzerland.ORCID 0000-0001-8885-6556
Tamara KanashovaMax-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany.
Yue HuInstitute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0003-3811-3206
Christoph OgrisInstitute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.
Annalisa MarsicoInstitute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.
Fabian TheisInstitute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-2419-1943
Michal PardoDepartment of Earth and Planetary Sciences, Faculty of Chemistry, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-6480-1171
Thomas GrögerJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Sebastian OederJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Jürgen OrascheJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Andreas PaulInstitute of Energy and Climate Research, Troposphere, Forschungszentrum Jülich GmbH, Jülich, Germany.
Till ZiehmInstitute of Energy and Climate Research, Troposphere, Forschungszentrum Jülich GmbH, Jülich, Germany.ORCID 0000-0001-5586-3709
Zhi-Hui ZhangDepartment of Environmental Sciences, University of Basel, Basel, Switzerland.
Thomas AdamJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Olli SippulaDepartment of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-6981-2694
Martin SklorzJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Jürgen Schnelle-KreisJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Hendryk CzechJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0001-8377-4252
Astrid Kiendler-ScharrInstitute of Energy and Climate Research, Troposphere, Forschungszentrum Jülich GmbH, Jülich, Germany.ORCID 0000-0003-3166-2253
Yinon RudichDepartment of Earth and Planetary Sciences, Faculty of Chemistry, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0003-3149-0201
Ralf ZimmermannJoint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany.
Helmholtz Zentrum München · DEForschungszentrum Jülich · DEUniversity of Eastern Finland · FIWeizmann Institute of Science · ILUniversity of Basel · CHCharles University · CZMax Delbrück Center · DEUniversity of Rostock · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSecondary organic aerosols (SOAs) formed from anthropogenic or biogenic gaseous precursors in the atmosphere substantially contribute to the ambient fine particulate matter [PM
objectivesWe aimed to discriminate toxicological effects of aerosols generated by atmospheric aging on combustion soot particles (SPs) of gaseous biogenic (
methodsMono- or cocultures of lung epithelial cells (A549) and endothelial cells (EA.hy926) were exposed at the ALI for 4 h to different aerosol concentrations of a photochemically aged mixture of primary combustion SP and
resultsWe observed considerable toxicity-related outcomes in cells treated with either SOA type. Greater adverse effects were measured for DISCUSSION: In this study using A549 and EA.hy926 cells exposed at ALI, SOA compounds had greater toxicity than primary SPs. Photochemical aging of naphthalene was associated with the formation of more oxidized, more aromatic SOAs with a higher oxidative potential and toxicity compared with
Indexed as
Air PollutantsSootAerosolsAgedAgingEndothelial CellsHumansLungParticulate MatterAerosolsAir PollutantsParticulate MatterSoot
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