Evidence map›Paper›PMID 35112923›Full record

ArticleJournal of the American Heart Association2022

Classic Thrombophilias and Thrombotic Risk Among Middle-Aged and Older Adults: A Population-Based Cohort Study.

Eric Manderstedt, Christina Lind-Halldén, Christer Halldén, Johan Elf, Peter J Svensson, Björn Dahlbäck, Gunnar Engström, Olle Melander, Aris Baras, Luca A Lotta and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

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  7. Thrombotic risk determined byResearch and practice in thrombosis and haemostasis · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Eric ManderstedtDepartment of Environmental Science and Bioscience Kristianstad University Kristianstad Sweden.
Christina Lind-HalldénDepartment of Environmental Science and Bioscience Kristianstad University Kristianstad Sweden.
Christer HalldénDepartment of Environmental Science and Bioscience Kristianstad University Kristianstad Sweden.ORCID 0000-0002-9355-3901
Johan ElfDepartment of Clinical Sciences Lund UniversitySkåne University Hospital Malmö Sweden.
Peter J SvenssonDepartment of Clinical Sciences Lund UniversitySkåne University Hospital Malmö Sweden.ORCID 0000-0003-2901-6877
Björn DahlbäckDepartment of Translational Medicine Lund UniversitySkåne University Hospital Malmö Sweden.
Gunnar EngströmDepartment of Clinical Sciences Lund UniversitySkåne University Hospital Malmö Sweden.ORCID 0000-0002-8618-9152
Olle MelanderDepartment of Clinical Sciences Lund UniversitySkåne University Hospital Malmö Sweden.
Aris BarasRegeneron Genetics Center Tarrytown NY.
Luca A LottaRegeneron Genetics Center Tarrytown NY.
Bengt ZöllerCenter for Primary Health Care Research Lund University and Region Skåne Malmö Sweden.ORCID 0000-0002-8250-5613
Regeneron Genetics Center 4 [Link]
Lund University · SERegeneron (United States) · USKristianstad University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Five classic thrombophilias have been recognized: factor V Leiden (rs6025), the prothrombin G20210A variant (rs1799963), and protein C, protein S, and antithrombin deficiencies. This study aimed to determine the thrombotic risk of classic thrombophilias in a cohort of middle-aged and older adults. Methods and Results Factor V Leiden, prothrombin G20210A and protein-coding variants in the

Indexed as

ThrombophiliaThrombosisVenous ThromboembolismAgedAnticoagulantsAntithrombinsCohort StudiesFactor VFemaleHumansMaleMiddle AgedMutationProtein CProtein SProthrombinAnticoagulantsAntithrombinsFactor VProtein CProtein SProthrombinepidemiologygeneticsnatural anticoagulantsthrombophiliavenous thromboembolism

Identifiers

PMID35112923
PMCPMC9245807
OpenAlexW4210360502

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.