ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
C-reactive protein levels and risk of dementia-Observational and genetic studies of 111,242 individuals from the general population.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 50 citations in OpenAlex.
- Dementia risk across distinct metabolic profiles in the UK Biobank.GeroScience · 2026Article
- Dissecting Alzheimer's proteomic landscape through NULISA profiling of brain cell-specific extracellular vesicles.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Mood Disorder Begins in the Mouth: Periodontitis Mediates Anxiety-Like Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Discovery-Driven Plasma Proteomics Identifies a Multi-Protein Signature for Amyloid PET Positivity: A Machine Learning Analysis of the Bio-Hermes Cohort.International journal of molecular sciences · 2026Article
- Delirium and Increased Risk of Developing Dementia: An Emulated Target Trial Analysis.medRxiv : the preprint server for health sciences · 2026Article
- [Plasma metabolites mediates the causal effect of inflammatory proteins on Alzheimer's disease: a Mendelian randomization study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.Brain communications · 2026Article
- Associations of circulating c-reactive protein levels with central Alzheimer's disease biomarkers.The journal of prevention of Alzheimer's disease · 2026Observational
- C-reactive protein and prospective cardiometabolic risk: observational and Mendelian randomization study of ischemic stroke and all-cause death.Cardiovascular diabetology · 2025Observational
- Association between neutrophil to lymphocyte ratio and Alzheimer's disease in large biobank cohorts.Journal of Alzheimer's disease : JAD · 2025Article
- Cardiovascular-kidney-metabolic syndrome, systemic inflammation, and incident dementia: evidence from 400,740 UK Biobank participants.Diabetology & metabolic syndrome · 2025Article
- Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a vicious cycle.Acta neuropathologica communications · 2025Article
- The association between religious beliefs and values with inflammation among Middle-age and older adults.Aging & mental health · 2024Article
- "Let's talk about sex, inflammaging, and cognition, baby": A meta-analysis and meta-regression of 106 case-control studies on mild cognitive impairment and Alzheimer's disease.Brain, behavior, & immunity - health · 2024Review
- The mediating role of systemic inflammation and moderating role of racialization in disparities in incident dementia.Communications medicine · 2024Article
- Genetic evidence for the causal effects of C-reactive protein on self-reported habitual sleep duration.Brain, behavior, & immunity - health · 2024Article
- Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.BMC geriatrics · 2024Article
- Stress-related cellular pathophysiology as a crosstalk risk factor for neurocognitive and psychiatric disorders.BMC neuroscience · 2023Review
- Peripheral immunity and risk of incident brain disorders: a prospective cohort study of 161,968 participants.Translational psychiatry · 2023Article
- Identification of circulating proteins associated with general cognitive function among middle-aged and older adults.Communications biology · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIncreased plasma levels of C-reactive protein (CRP) in midlife are associated with increased risk of Alzheimer's disease (AD), whereas in older age the opposite association is observed. Whether genetically determined CRP is associated with AD remains unclear.
methodsA total of 111,242 White individuals from the Copenhagen General Population Study and the Copenhagen City Heart Study were included. Plasma levels of CRP and four regulatory genetic variants in the CRP gene were determined.
resultsFor CRP percentile group 1 to 5 (lowest plasma CRP) versus the 50 to 75 group (reference), the hazard ratio for AD was 1.69 (95% confidence interval 1.29-2.16). Genetically low CRP was associated with increased risk of AD in individuals with body mass index ≤25 kg/m DISCUSSION: Low plasma levels of CRP at baseline were associated with high risk of AD in individuals from the general population. These observational findings were supported by genetic studies.
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