Evidence map›Paper›PMID 35112212›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

Vasomotor symptoms in early breast cancer-a "real world" exploration of the patient experience.

Katherine Marie Cole, Mark Clemons, Mashari Alzahrani, Michelle Liu, Gail Larocque, Fiona MacDonald, Brian Hutton, Ardelle Piper, Ricardo Fernandes, Gregory R Pond and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. A mixed studies systematic review of the unmet treatment, support, and information needs of cancer survivors in managing menopause symptoms.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Using machine learning to predict individual patient toxicities from cancer treatments.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Katherine Marie ColeDivision of Medical Oncology, Department of Medicine, The Ottawa Hospital, The University of Ottawa, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.
Mark ClemonsDivision of Medical Oncology, Department of Medicine, The Ottawa Hospital, The University of Ottawa, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.
Mashari AlzahraniDivision of Medical Oncology, Department of Medicine, The Ottawa Hospital, The University of Ottawa, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.
Michelle LiuCancer Therapeutics Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Gail LarocqueThe Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.
Fiona MacDonaldThe Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.
Brian HuttonClinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Ardelle PiperUniversity of Ottawa Health Services, Ottawa, ON, Canada.
Ricardo FernandesDivision of Medical Oncology, Department of Oncology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Gregory R PondDepartment of Oncology, McMaster University, Hamilton, ON, Canada.
Lisa VandermeerCancer Therapeutics Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Khaled El EmamCHEO Research Institute and the School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
Sharon F McGeeDivision of Medical Oncology, Department of Medicine, The Ottawa Hospital, The University of Ottawa, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada. shmcgee@toh.ca.ORCID http://orcid.org/0000-0002-0323-6372
Ottawa Hospital · CAUniversity of Ottawa · CAMcMaster University · CAOntario Institute for Cancer Research · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the frequency of vasomotor symptoms (VMS) in patients with early breast cancer (EBC), their optimal management remains unknown. A patient survey was performed to determine perspectives on this important clinical challenge.

methodsPatients with EBC experiencing VMS participated in an anonymous survey. Patients reported on the frequency and severity of VMS using the validated Hot Flush Rating Scale (HFRS) and ranked their most bothersome symptoms. Respondents were also asked to determine endpoints that defined effective treatment of VMS and report on the effectiveness of previously tried interventions.

resultsResponses were received from 373 patients, median age 56 years (range 23-83), who experienced an average of 5.0 hot flashes per day (SD 6.57). Patients reported the most bothersome symptoms to be feeling hot/sweating (155/316, 49%) and sleeping difficulties (86/316, 27%). Fifty-five percent (201/365) of patients would consider a treatment to be effective if it reduced night-time awakenings. While 68% of respondents were interested in trying interventions from their healthcare team to manage VMS, only 18% actually did so. Of the 137 patients who had tried an intervention for VMS, pharmacological treatments, exercise, and relaxation strategies were more likely to be effective, while therapies such as melatonin and black cohosh were deemed less effective.

conclusionVMS are a common and bothersome problem for EBC patients, with a minority receiving interventions to manage these symptoms. Further research is needed to identify patient-centered strategies for managing these distressing symptoms.

Indexed as

Breast NeoplasmsAdultAgedAged, 80 and overFemaleHot FlashesHumansMenopauseMiddle AgedPatient Outcome AssessmentSweatingYoung AdultBreast cancerHot flashesSurvivorshipVasomotor symptoms

Identifiers

PMID35112212
PMCPMC8809216
OpenAlexW4210652248

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.