Evidence map›Paper›PMID 35112125›Full record

ArticleChemical communications (Cambridge, England)2022

The yin and yang of intracellular delivery of amphipathic optical probes using

Hitesh K Agarwal, Radoslav Janicek, Jun Zhao, Karthik Sambath, Marcel Egger, Ernst Niggli, Graham C R Ellis-Davies

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hitesh K AgarwalDepartment of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA. graham.davies@mssm.edu.
Radoslav JanicekDepartment of Physiology, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-8924-1024
Jun ZhaoDepartment of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA. graham.davies@mssm.edu.
Karthik SambathDepartment of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA. graham.davies@mssm.edu.
Marcel EggerDepartment of Physiology, University of Bern, Bern, Switzerland.
Ernst NiggliDepartment of Physiology, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0003-4670-4903
Graham C R Ellis-DaviesDepartment of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA. graham.davies@mssm.edu.ORCID http://orcid.org/0000-0003-4179-5455
Icahn School of Medicine at Mount Sinai · USUniversity of Bern · CHSouth University · US

Funding

PHOTOCHEMICAL REGULATION OF CALCIUM IN CELL PHYSIOLOGYR01GM053395 · NIGMS · OREGON HEALTH AND SCIENCE UNIVERSITY · PI ELLIS-DAVIES, GRAHAM · 1995 to 2020
$6.1M
Light-Driven Control of Neurons in Vitro and in VivoR35NS111600 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Graham Ellis-Davies · 2019 to 2026
$5.5M
NIGMS NIH HHS R01 GM053395NINDS NIH HHS R35 NS111600
6 · The paper itself

Abstract

Monitoring and manipulation of ionized intracellular calcium concentrations within intact, living cells using optical probes with organic chromophores is a core method for cell physiology. Since all these probes have multiple negative charges, they must be smuggled through the plasma membrane in a transiently neutral form, with intracellular esterases used to deprotect the masked anions. Here we explore the ability of the synthetically easily accessible

Indexed as

CalciumCell MembraneCytosolEsterasesFluorescent DyesHumansMolecular StructureMyocytes, CardiacParticle SizeCalciumEsterasesFluorescent Dyes

Identifiers

PMID35112125
PMCPMC9502023
OpenAlexW4210377382

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.