Evidence map›Paper›PMID 35112094›Full record

ArticleAmerican journal of preventive cardiology2022

Inflammatory bowel disease and atherosclerotic cardiovascular disease in U.S. adults-A population-level analysis in the national health interview survey.

Khurram Nasir, Isaac Acquah, Amit K Dey, Tanushree Agrawal, Syed Zawahir Hassan, Kerri Glassner, Bincy Abraham, Eamonn M M Quigley, Ron Blankstein, Salim S Virani and 4 more

Open access · goldAbstract read
In one paragraph

Article in American journal of preventive cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  7. Acute Coronary Syndrome and Rheumatic Disease.Journal of clinical medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Khurram NasirDivision of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, MD, United States.
Isaac AcquahDivision of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, MD, United States.
Amit K DeyDepartment of Medicine, MedStar Union Memorial Hospital, Baltimore, MD, United States.
Tanushree AgrawalDivision of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, MD, United States.
Syed Zawahir HassanDivision of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, MD, United States.
Kerri GlassnerDivision of Gastroenterology, Lynda K and David M Underwood Center for Digestive Disorders, Houston Methodist Hospital, Houston, MD, United States.
Bincy AbrahamDivision of Gastroenterology, Lynda K and David M Underwood Center for Digestive Disorders, Houston Methodist Hospital, Houston, MD, United States.
Eamonn M M QuigleyDivision of Gastroenterology, Lynda K and David M Underwood Center for Digestive Disorders, Houston Methodist Hospital, Houston, MD, United States.
Ron BlanksteinCardiovascular Imaging Program, Department of Medicine and Radiology, Brigham and Women's Hospital, Boston, MD, United States.
Salim S ViraniMichael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, MD, United States.
Michael J BlahaCiccarone Center for Prevention of Cardiovascular Disease, Johns Hopkins University, Baltimore, MD, United States.
Javier Valero-ElizondoDivision of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, MD, United States.
Miguel Cainzos-AchiricaDivision of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, MD, United States.
Nehal N MehtaSection of Inflammation and Cardiometabolic Diseases National Institutes of Health, Bethesda, MD, United States.
Houston Methodist · USMethodist Hospital · USBaylor College of Medicine · USBrigham and Women's Hospital · USJohns Hopkins University · USMedStar Union Memorial Hospital · USNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the association between inflammatory bowel disease (IBD) and atherosclerotic cardiovascular disease (ASCVD) and whether this association is modified by age or sex.

methodsWe conducted a cross-sectional analysis using data from the 2015-2016 National Health Interview Survey (NHIS). The exposure of interest was self-reported IBD. The outcome of interest was prevalent ASCVD, which included a history of angina, myocardial infarction or stroke. We used survey-specific descriptive statistics to obtain weighted national estimates for IBD and ASCVD prevalence. Logistic regression models were used to assess the association between IBD and ASCVD, progressively adjusting for demographics and traditional risk factors. Effect modification by age and sex was evaluated.

resultsAmong participants with IBD, the age-adjusted prevalence of ASCVD was 12.0% compared to 6.9% among those without IBD (

conclusionOur analysis confirms an independent association between IBD and ASCVD in the U.S., particularly among young adults. Further studies are needed to fully establish a causal relationship between IBD and ASCVD, characterize the mechanisms underlying these associations, and identify tailored opportunities for ASCVD prevention in young and middle-aged adults with IBD.

Indexed as

ACC/AHA, American College of Cardiology/American Heart AssociationASCVD, atherosclerotic cardiovascular diseaseCardiovascular diseaseCI, confidence intervalIBD, Inflammatory bowel diseaseInflammationNHIS, National Health Interview SurveyPreventionYoung adults

Identifiers

PMID35112094
PMCPMC8790599
OpenAlexW4206488562

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.