Evidence map›Paper›PMID 35112086›Full record

ArticleSTAR protocols2022

Protocol for behavioral and neural recording during stimulation of the macaque monkey nucleus basalis.

Xue-Lian Qi, Kendyl R Pennington, Christopher Banerjee, Fernando L Vale, Sarah K Bick, Dario J Englot, Robert S Turner, Christos Constantinidis, David T Blake

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in STAR protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Xue-Lian QiDepartment of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Kendyl R PenningtonDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Christopher BanerjeeDepartment of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Fernando L ValeDepartment of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Sarah K BickDepartment of Neurological Surgery, Vanderbilt University, Nashville, TN 37212, USA.
Dario J EnglotDepartment of Neurological Surgery, Vanderbilt University, Nashville, TN 37212, USA.
Robert S TurnerDepartment Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Christos ConstantinidisDepartment Biomedical Engineering, Vanderbilt University School of Medicine, Nashville, TN 37235, USA.
David T BlakeDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Augusta University · USVanderbilt University · USUniversity of Pittsburgh · USWake Forest University · US

Funding

Primate model of deep brain stimulation for Alzheimers and age-related cognitivedeclineRF1AG060754 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BLAKE, DAVID T, CONSTANTINIDIS, CHRISTOS · 2019 to 2019
$3.9M
NEUROMODULATOR INFLUENCES ON PREFRONTAL CORTICAL FUNCTIONR01MH097695 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BLAKE, DAVID T, CONSTANTINIDIS, CHRISTOS · 2013 to 2017
$1.9M
NIA NIH HHS RF1 AG060754NIMH NIH HHS R01 MH097695
6 · The paper itself

Abstract

We present an experimental protocol to record neuronal activity during intermittent stimulation of nucleus basalis (NB), as macaque monkeys perform cognitive tasks. This protocol includes implantation of electrodes and generator devices to deliver electrical stimulation to NB using multiple approaches in monkeys. Direct stimulation of NB avoids peripheral cholinergic side effects, optimizes timing, and activates non-cholinergic projection neurons. We describe electrode preparation, surgery, and implantation for direct evaluation of how stimulation affects monkeys' behavior and neuronal activity. For complete details on the use and execution of this profile, please refer to Qi et al. (2021).

Indexed as

Basal Nucleus of MeynertMacacaAnimalsElectric StimulationHaplorhiniNeuronsBehaviorCognitive NeuroscienceModel OrganismsNeuroscience

Identifiers

PMID35112086
PMCPMC8790678
OpenAlexW4206969827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.