Evidence map›Paper›PMID 35112032›Full record

ArticleAmerican journal of ophthalmology case reports2022

Treatment of recalcitrant Acanthamoeba Keratitis with Photoactivated Chromophore for Infectious Keratitis Corneal Collagen Cross-Linking (PACK-CXL).

Shelly H Watson, Nakul S Shekhawat, Yassine J Daoud

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Oxidative Stress and Redox Imbalance inInternational journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. New Frontiers inBiology · 2023
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shelly H WatsonWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Nakul S ShekhawatWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Yassine J DaoudWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

Improving Outcomes Assessment for Microbial KeratitisK23EY032988 · NEI · JOHNS HOPKINS UNIVERSITY · PI Nakul Shekhawat · 2022 to 2026
$1.1M
NEI NIH HHS K23 EY032988
6 · The paper itself

Abstract

purposeTo describe a case of recalcitrant Acanthamoeba Keratitis (AK) complicated by medical non-compliance and medication intolerance that was successfully treated with photoactivated chromophore for infectious keratitis corneal collagen cross-linking (PACK-CXL). OBSERVATIONS: A 31-year-old male presented with right eye pain and redness in the setting of fresh water exposure and scleral contact lens wear. He had lack of a response to treatment with antiviral therapy for 3 months by an outside provider. Cultures were found to be positive for

conclusionPACK-CXL was associated with a dramatic improvement in a case of recalcitrant

Indexed as

AcanthamoebaCrosslinkingKeratitisMiltefosinePACK-CXL

Identifiers

PMID35112032
PMCPMC8790275
OpenAlexW4206920359

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.