Evidence map›Paper›PMID 35111996›Full record

ArticleJournal of veterinary research2021

The Protective Action of Piperlongumine Against Mycobacterial Pulmonary Tuberculosis in Its Mitigation of Inflammation and Macrophage Infiltration in Male BALB/c Mice.

Nihong Lu, Yongrui Yang, Xiaofei Li, Jie Li, Jie Cheng, Zhengxuan Lv, Yingrong Du

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nihong LuDepartment of Respiratory and Critical Care, The Third People's Hospital of Kunming, Kunming, Yunnan, 650041 China.
Yongrui YangDepartment of Respiratory and Critical Care, The Third People's Hospital of Kunming, Kunming, Yunnan, 650041 China.
Xiaofei LiDepartment of Respiratory and Critical Care, The Third People's Hospital of Kunming, Kunming, Yunnan, 650041 China.
Jie LiDepartment of Respiratory and Critical Care, The Third People's Hospital of Kunming, Kunming, Yunnan, 650041 China.
Jie ChengDepartment of Respiratory and Critical Care, The Third People's Hospital of Kunming, Kunming, Yunnan, 650041 China.
Zhengxuan LvDepartment of Respiratory and Critical Care, The Third People's Hospital of Kunming, Kunming, Yunnan, 650041 China.
Yingrong DuDepartment of Respiratory and Critical Care, The Third People's Hospital of Kunming, Kunming, Yunnan, 650041 China.
Kunming Third People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPiperlongumine (PL) is a bioactive alkaloid and medicinal compound of piperamide isolated from the long pepper ( MATERIAL AND

methods

resultsPiperlongumine inhibited inflammatory mediators and adherence of lymphocyte function-associated antigen 1 to MH-S cells following TDM activation. It also improved macrophage clearance of MTB. In TDM-stimulated MH-S cells, PL significantly influenced the macrophage inducible Ca

conclusionPL as an inhibitor of MTB-triggered granulomatous inflammation may be an effective complementary treatment for mycobacterial infection.

Indexed as

inflammationmacrophagesMinclepiperlonguminetuberculosis

Identifiers

PMID35111996
PMCPMC8775741
OpenAlexW3215396075

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.