Evidence map›Paper›PMID 35111953›Full record

ReviewBioengineering & translational medicine2022

Polylysine for skin regeneration: A review of recent advances and future perspectives.

Payam Zarrintaj, Sadegh Ghorbani, Mahmood Barani, Narendra Pal Singh Chauhan, Mohsen Khodadadi Yazdi, Mohammad Reza Saeb, Joshua D Ramsey, Michael R Hamblin, Masoud Mozafari, Ebrahim Mostafavi

Open access · goldAbstract readReview
In one paragraph

Review in Bioengineering & translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 6 countries.

Payam ZarrintajSchool of Chemical Engineering Oklahoma State University Stillwater Oklahoma USA.
Sadegh GhorbaniInterdisciplinary Nanoscience Center (iNANO) Aarhus University Aarhus Denmark.
Mahmood BaraniMedical Mycology and Bacteriology Research Center Kerman University of Medical Sciences Kerman Iran.
Narendra Pal Singh ChauhanDepartment of Chemistry, Faculty of Science Bhupal Nobles' University Udaipur Rajasthan India.
Mohsen Khodadadi YazdiSchool of Chemistry, College of Science University of Tehran Tehran Iran.
Mohammad Reza SaebDepartment of Polymer Technology, Faculty of Chemistry Gdańsk University of Technology Gdańsk Poland.ORCID https://orcid.org/0000-0001-9907-9414
Joshua D RamseySchool of Chemical Engineering Oklahoma State University Stillwater Oklahoma USA.
Michael R HamblinLaser Research Centre, Faculty of Health Science University of Johannesburg South Africa.
Masoud MozafariDepartment of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine Iran University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0002-0232-352X
Ebrahim MostafaviStanford Cardiovascular Institute Stanford University School of Medicine Stanford California USA.ORCID https://orcid.org/0000-0003-3958-5002
Oklahoma State University · USAarhus University · DKCardiovascular Institute of the South · USGdańsk University of Technology · PLIran University of Medical Sciences · IRKerman University of Medical Sciences · IRUniversity of Johannesburg · ZAUniversity of Rajasthan · INUniversity of Tehran · IR

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Multi-Disciplinary Training Program in Cardiovascular Imaging at StanfordT32EB009035 · NIBIB · STANFORD UNIVERSITY · PI Koen Nieman, John M. Pauly · 2008 to 2026
$4.3M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
NIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700NIBIB NIH HHS T32 EB009035
6 · The paper itself

Abstract

There have been several attempts to find promising biomaterials for skin regeneration, among which polylysine (a homopolypeptide) has shown benefits in the regeneration and treatment of skin disorders. This class of biomaterials has shown exceptional abilities due to their macromolecular structure. Polylysine-based biomaterials can be used as tissue engineering scaffolds for skin regeneration, and as drug carriers or even gene delivery vectors for the treatment of skin diseases. In addition, polylysine can play a preservative role in extending the lifetime of skin tissue by minimizing the appearance of photodamaged skin. Research on polylysine is growing today, opening new scenarios that expand the potential of these biomaterials from traditional treatments to a new era of tissue regeneration. This review aims to address the basic concepts, recent trends, and prospects of polylysine-based biomaterials for skin regeneration. Undoubtedly, this class of biomaterials needs further evaluations and explorations, and many critical questions have yet to be answered.

Indexed as

cationic polymerpolyelectrolytepoly‐l‐lysineregenerative medicinetissue engineering

Identifiers

PMID35111953
PMCPMC8780928
OpenAlexW3205150828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.