ArticleJournal of arthropod-borne diseases2021
Level of Pyrethroid-Resistance Associated with Cytochrome P450 Expression in German Cockroach
Article in Journal of arthropod-borne diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 2 citations in OpenAlex.
- Molecular Characterization of Cytochrome P450 Genes (CYP9M10 and CYP4H34) in Insecticide-Resistant and Susceptible Strains ofJournal of arthropod-borne diseases · 2026Article
- Status and Mechanism of Insecticide Resistance in German Cockroach (Tropical life sciences research · 2025Review
- Development and Optimization of a Nanoparticle-Based Imidacloprid Insecticide for Effective Control ofJournal of arthropod-borne diseases · 2024Article
- Susceptibility Status of Several Field-Collected German Cockroaches (Iranian journal of public health · 2024Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCytochrome P450-dependent monooxygenases are a very important metabolic system involve in insecticide resistance. This study was conducted to find the association between the expression level of cytochrome P450 (CYP450) and permethrin-resistance level among four strains of the German cockroach
methodsThree field strains of German cockroach with different frequency of exposure to pesticides, and a laboratory susceptible strain were used in the present study. Insecticide susceptibility bioassays were carried out to detect resistance to permethrin. The concentration of CYP450 in each strain was determined using ion-exchange HPLC chromatography. Biochemical assays was performed to analyse CYP450 activities.
resultsThe resistance ratios (RR) to permethrin among three field strains were 3.29, 4.10 and 6.17-fold comping with the susceptible stain. The CYP450 activity of three field strains was 1.6, 2.4 and 2.7 times higher than in the susceptible stain. The amount of CYP450 per mg of protein was significantly different between the susceptible and the three resistant strains. The resistant cockroaches showed a relatively high expression of CYP450 enzymes. A strong correlation was found between permethrin resistance level and total concentration of CYP450 enzymes.
conclusionThe results of current study show that more frequent usage of a pyrethroid insecticide cause the metabolic insecticide resistance to rise in German cockroach. Therefore, there is a ratio correlation between resistance level and monooxygenases activities in insect. Thus, the control program must be managed according to history of pesticide usage.
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