Evidence map›Paper›PMID 35111768›Full record

ArticleFrontiers in medicine2021

The Relationship Between Plasma Tetrahydrocannabinol Levels and Intraocular Pressure in Healthy Adult Subjects.

Sameh Mosaed, Andrew K Smith, John H K Liu, Donald S Minckler, Robert L Fitzgerald, David Grelotti, Emily Sones, Robert N Weinreb, Thomas D Marcotte

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sameh MosaedGavin Herbert Eye Institute, University of California, Irvine, Irvine, CA, United States.
Andrew K SmithGavin Herbert Eye Institute, University of California, Irvine, Irvine, CA, United States.
John H K LiuViterbi Family Department of Ophthalmology, University of California, San Diego, San Diego, CA, United States.
Donald S MincklerIrvine School of Medicine, University of California, Irvine, Irvine, CA, United States.
Robert L FitzgeraldDepartment of Pathology, University of California, San Diego, San Diego, CA, United States.
David GrelottiDepartment of Psychiatry, University of California, San Diego, San Diego, CA, United States.
Emily SonesDepartment of Psychiatry, University of California, San Diego, San Diego, CA, United States.
Robert N WeinrebViterbi Family Department of Ophthalmology, University of California, San Diego, San Diego, CA, United States.
Thomas D MarcotteDepartment of Psychiatry, University of California, San Diego, San Diego, CA, United States.
University of California, San Diego · USUniversity of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundΔ9-tetrahydrocannabinol (THC) has been shown to decreased intraocular pressure (IOP). This project aims to define the relationship between plasma THC levels and IOP in healthy adult subjects.

methodsEleven healthy subjects received a single dose of inhaled cannabis that was self-administered in negative pressure rooms. Measurements of IOP and plasma THC levels were taken at baseline and every 30 min for 1 h and afterwards every hour for 4 h. IOP reduction and percent change in IOP over time were calculated. Linear regression models were used to measure the relationship between IOP and plasma THC levels. Two line linear regression models with F-tests were used to detect change points in the regression. Then, Pearson correlations were computed based on the change point.

resultsTwenty-two eyes met inclusion criteria. The average peak percentage decrease in IOP was 16% at 60 min. Percent IOP reduction as well as total IOP reduction demonstrated a negative correlation with THC plasma levels showing r-values of -0.81 and -0.70, respectively.

conclusionPlasma THC levels are significantly correlated with IOP reduction up to plasma levels of 20 ng/ml. Plasma levels >20 ng/ml were not correlated with further decrease in IOP. More research is needed to determine the efficacy of THC in reducing IOP for eyes with ocular hypertension and glaucoma.

Indexed as

cannabisglaucomaintraocular pressure (IOP)tetrahydrocannabinol (THC)treatment

Identifiers

PMID35111768
PMCPMC8801518
OpenAlexW4206228486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.