ArticleQuantitative imaging in medicine and surgery2022
Prediction of high nodal burden in invasive breast cancer by quantitative shear wave elastography.
Article in Quantitative imaging in medicine and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 14 citations in OpenAlex.
- Trimethylamine N-oxide as a potential biomarker for predicting axillary lymph node metastasis in breast cancer: a retrospective study.World journal of surgical oncology · 2026Article
- A non-invasive preoperative model for predicting sentinel lymph node metastasis in breast cancer using clinical data and MRI.BMC medical imaging · 2025Article
- Bi-modal ultrasound radiomics and habitat analysis enhanced the pre-operative prediction of axillary lymph node burden in patients with early-stage breast cancer.Frontiers in oncology · 2025Article
- Ultrasound elastography features as promising predictors of pathological complete response in patients with HER2-positive breast cancer undergoing neoadjuvant therapy.American journal of translational research · 2025Article
- Value of intra- and peritumoral ultrasound radiomics for predicting axillary lymph node burden in breast cancer.Frontiers in oncology · 2025Article
- The value of microvascular Doppler ultrasound technique, qualitative or quantitative shear-wave elastography of breast lesions for predicting axillary nodal burden in patients with breast cancer.Quantitative imaging in medicine and surgery · 2024Article
- The course and prognostic value of tumor stiffness detected by ultrasound elastography for transarterial chemoembolization of hepatocellular carcinoma.Quantitative imaging in medicine and surgery · 2023Article
- Article
- Clinical studies of magnetic resonance elastography from 1995 to 2021: Scientometric and visualization analysis based on CiteSpace.Quantitative imaging in medicine and surgery · 2022Article
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7 authors at 2 institutions in 1 country.
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Abstract
backgroundAxillary imaging has been earmarked to forecast high nodal burden [≥3 metastatic axillary lymph nodes (ALN)] instead of lymph node metastasis since the Z0011 trial period. We aimed to ascertain the possibility of utilising quantitative shear wave elastography (SWE) to forecast high nodal burden in invasive breast cancer (IBC).
methodsIn our hospital, 324 patients with clinical T1-T2N0 IBC who underwent surgery from June 2020 to October 2020 were analyzed retrospectively. A total of 273 patients (84.3%) were categorized as having a limited nodal burden, while 51 patients (15.7%) had a high nodal burden. The two groups were compared in terms of clinicopathological traits, ultrasonic features, and SWE values. The diagnostic performance for prediction of high nodal burden with the optimal cutoff values was drawn by SWE value.
resultsThe optimal cutoff values for forecasting high nodal burden were as demonstrated: 119.52 kPa for tumor Emax, 97.31 kPa for tumor Emean, 19.38 for tumor Esd, 26.22 kPa for ALN Emax, 19.79 kPa for ALN Emean, 2.32 for ALN Eratio, 3.34 for ALN Esd. Combined with the ratings of sensitivity and specificity, ALN Emax could be chosen as the optimal index if the best diagnostic achievement was contemplated (AUC: 0.856; 95% CI: 0.802-0.909).
conclusionsAn Emax cutoff 26.22 kPa of ALN, 72% of women with a high nodal burden of axillary disease would be detected, but if used for clinical decision making, 13% of women with a limited nodal burden disease would be potentially over treated. This data can allow us to appropriately ascertain this subgroup and can be used as one of the therapeutic implementation resources for patient decision support.
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