ArticleQuantitative imaging in medicine and surgery2022
Hemodynamic features underlying pulmonary vein stump thrombus formation after left upper lobectomy: four-dimensional flow magnetic resonance imaging study.
Article in Quantitative imaging in medicine and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Impact of Left Atrial Hemodynamics on the Development of Pulmonary Vein Stump Thrombus: Results of Early and Late Postoperative Studies.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2026Article
- Pulmonary Vein Stump: A Left Atrial Cardioembolic Source.JACC. Case reports · 2025Article
- Association between left atrial function and pulmonary vein stump thrombus after left upper lobectomy: insights from cine-MRI.Scientific reports · 2025Article
- Acute Myocardial Infarction Caused by Pulmonary Vein Stump Thrombosis after Thoracoscopic Left Upper Lobectomy.Surgical case reports · 2025Article
- Pulmonary vein stump thrombosis and organ infarction after lung lobectomy.Journal of anesthesia · 2024Review
- Proximal ligation technique prevents thrombus formation in the pulmonary vein stump after lobectomy.Surgery today · 2024Article
- Stagnating blood flow related to thrombus formation in pulmonary vein stump after left upper lobectomy.General thoracic and cardiovascular surgery · 2023Article
- Left atrial CT volume and CHAScientific reports · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe previously reported that to-and-fro blood movement near the pulmonary vein stump was particularly prominent after left upper lobectomy compared with other lobectomy, which may be the cause of the high susceptibility of pulmonary vein thrombus after left upper lobectomy. The aim of the present study was to compare the hemodynamics in patients who developed pulmonary vein thrombus after left upper lobectomy with those in patients who did not develop pulmonary vein thrombus using four-dimensional flow magnetic resonance imaging (4D MRI).
methodsThis was a retrospective evaluation of a prospectively collected clinical and radiological database of 37 patients who underwent 4D MRI 7 days after left upper lobectomy for lung cancer (n=37). We obtained two parameters by 4D MRI: the grade of to-and-fro blood movement and the flow energy loss around the pulmonary vein stump. The length of the pulmonary vein stump, a known risk factor for pulmonary vein thrombus, was also measured.
resultsAccording to a scatterplot of the grade of to-and-fro blood movement versus the flow energy loss, patients with pulmonary vein thrombus (n=15) were concentrated in an area which appears to be a 'dangerous' hemodynamic condition. There were few patients without pulmonary vein thrombus in this 'dangerous' area, except for one who unfortunately developed delayed pulmonary vein thrombus and cerebral infarction. We proposed a formula using the 4D MRI-derived parameters based on a stepwise multiple regression analysis that was more closely associated with the development of pulmonary vein thrombus than the length of the pulmonary vein stump (area under the receiver operating characteristics curve: 0.918
conclusionsWe proposed the existence of a 'dangerous' hemodynamic condition responsible for pulmonary vein thrombus formation. 4D MRI before the development of pulmonary vein thrombus may help identify patients requiring preventive therapy against pulmonary vein thrombus and subsequent thromboembolic complications.
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