Evidence map›Paper›PMID 35111324›Full record

ArticleMolecular and clinical oncology2022

Expression of PD-L1 and CD4+ tumor-infiltrating lymphocytes predict survival in head and neck squamous cell carcinoma.

Ze-Ming Fu, De-Jun Zhang, Ying-Yuan Guo, Shuang Han, Fang Guo, Jie Bai, Yi-Ning Wan, Guo-Fang Guan, Ke-Wei Sun, Na Yang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Identifying factors for pembrolizumab eligibility in head and neck cancer.Journal of cancer research and clinical oncology · 2025
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ze-Ming FuDepartment of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
De-Jun ZhangDepartment of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
Ying-Yuan GuoDepartment of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
Shuang HanDepartment of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
Fang GuoDepartment of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
Jie BaiDepartment of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
Yi-Ning WanDepartment of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
Guo-Fang GuanDepartment of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
Ke-Wei SunDepartment of Otolaryngology-Head and Neck Surgery, Changchun Center Hospital, Changchun, Jilin 130041, P.R. China.
Na YangDepartment of Otolaryngology-Head and Neck Surgery, Changchun Center Hospital, Changchun, Jilin 130041, P.R. China.
Second Affiliated Hospital of Jilin University · CNChangchun Obstetrics and Gynecology Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical efficacy of immune checkpoint blockade has been recently demonstrated in a variety of cancer types. The aim of the present study was to characterize the expression profile of tumor-infiltrating lymphocytes (TILs) and programmed death-ligand 1 (PD-L1) in head and neck squamous carcinoma (HNSCC). A total of 63 patients with HNSCC were enrolled in the present study. CD3

Indexed as

head and neck squamous cell carcinomaPD-L1prognostic valuetumor-infiltrating lymphocytes

Identifiers

PMID35111324
PMCPMC8771311
OpenAlexW4206424290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.