ArticleFrontiers in immunology2021
Integrating RNA-Seq With GWAS Reveals a Novel SNP in Immune-Related
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Candidate gene polymorphisms associated with silicosis and coal workers' pneumoconiosis: a systematic review and meta-analysis.BMC pulmonary medicine · 2024Pooled it
- Data-intensive immune network modelling for One Health.Briefings in bioinformatics · 2026Review
- Diagnosing Pleural Effusion Caused by Silicosis in a Long-Term Quarry Worker: A Case Report.International medical case reports journal · 2025Article
- Review
- Integration of apaQTL and eQTL analysis reveals novel SNPs associated with occupational pulmonary fibrosis risk.Archives of toxicology · 2024Article
- Evidence for immune activation in pathogenesis of the HLA class II associated disease, podoconiosis.Nature communications · 2024Article
- The systemic immune-inflammation index is significantly associated with the severity of silicosis: a 9-year retrospective study in Beijing.Frontiers in medicine · 2024Article
- Strategies adopted by Salmonella to survive in host: a review.Archives of microbiology · 2023Review
- Artesunate targets cellular metabolism to regulate the Th17/Treg cell balance.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- Traumatic brain injury induces an adaptive immune response in the meningeal transcriptome that is amplified by aging.Frontiers in neuroscience · 2023Article
- Role of Genetic Polymorphisms inInternational journal of chronic obstructive pulmonary disease · 2022Article
- Coenzyme Q10 Alleviates Silicosis FibrosisIn vivo (Athens, Greece)Article
- Sculpting - A Modern Menace.Indian journal of occupational and environmental medicineArticle
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the association between single-nucleotide polymorphisms (SNPs) in RNA-seq identified mRNAs and silicosis susceptibility. Methods: A comprehensive RNA-seq was performed to screen for differently expressed mRNAs in the peripheral blood lymphocytes of eight subjects exposed to silica dust (four silicosis cases and four healthy controls). Following this, the SNPs located on the shortlisted mRNAs, which may affect silicosis susceptibility, were screened through silicosis-related genome-wide association studies (GWAS) (155 silicosis cases and 141 healthy controls), whereas functional expression quantitative trait locus (eQTL)-SNPs were identified using the GTEx database. Finally, the association between functional eQTL-SNPs and silicosis susceptibility (194 silicosis cases and 235 healthy controls) was validated. Results: A total of 70 differentially expressed mRNAs (fold change > 2 or fold change < 0.5, Conclusion: The mutant A allele of rs9273410 was associated with increased silicosis susceptibility by modulating the expression of
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Registered trials
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