ReviewFrontiers in physiology2021
Airway Closure and Expiratory Flow Limitation in Acute Respiratory Distress Syndrome.
Review in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Distribution of airway pressure opening in the lungs measured with electrical impedance tomography (POET): a prospective physiological study.Critical care (London, England) · 2025Trial
- The impact of head and thorax elevation on respiratory mechanics during cardiopulmonary resuscitation: a multi-model study.Resuscitation plus · 2026Article
- Airway closure in a patient with acute heart failure: a case report.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Article
- Development of an acute lung injury model for drug testing.Scientific reports · 2025Article
- Respiratory training reduces postoperative pulmonary complications in elderly gynecological patients undergoing general anesthesia.American journal of translational research · 2025Article
- Airway epithelium damage in acute respiratory distress syndrome.Critical care (London, England) · 2024Article
- Detecting Intrathoracic Airway Closure during Prehospital Cardiopulmonary Resuscitation Using Quasi-Static Pressure-Volume Curves: A Pilot Study.Journal of clinical medicine · 2024Article
- Article
- Airway opening pressure maneuver to detect airway closure in mechanically ventilated pediatric patients.Frontiers in pediatrics · 2024Article
- Respiratory Mechanics: Revisiting the Appraisement of Lung Recruitment.Respiratory care · 2023Review
- MircroRNA Let-7a-5p in Airway Smooth Muscle Cells is Most Responsive to High Stretch in Association With Cell Mechanics Modulation.Frontiers in physiology · 2022Article
- Attenuation of the Severity of Acute Respiratory Distress Syndrome by Pomiferin through Blocking Inflammation and Oxidative Stress in an AKT/Foxo1 Pathway-Dependent Manner.Oxidative medicine and cellular longevity · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute respiratory distress syndrome (ARDS) is mostly characterized by the loss of aerated lung volume associated with an increase in lung tissue and intense and complex lung inflammation. ARDS has long been associated with the histological pattern of diffuse alveolar damage (DAD). However, DAD is not the unique pathological figure in ARDS and it can also be observed in settings other than ARDS. In the coronavirus disease 2019 (COVID-19) related ARDS, the impairment of lung microvasculature has been pointed out. The airways, and of notice the small peripheral airways, may contribute to the loss of aeration observed in ARDS. High-resolution lung imaging techniques found that in specific experimental conditions small airway closure was a reality. Furthermore, low-volume ventilator-induced lung injury, also called as atelectrauma, should involve the airways. Atelectrauma is one of the basic tenet subtending the use of positive end-expiratory pressure (PEEP) set at the ventilator in ARDS. Recent data revisited the role of airways in humans with ARDS and provided findings consistent with the expiratory flow limitation and airway closure in a substantial number of patients with ARDS. We discussed the pattern of airway opening pressure disclosed in the inspiratory volume-pressure curves in COVID-19 and in non-COVID-19 related ARDS. In addition, we discussed the functional interplay between airway opening pressure and expiratory flow limitation displayed in the flow-volume curves. We discussed the individualization of the PEEP setting based on these findings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.