Evidence map›Paper›PMID 35110995›Full record

ArticleFrontiers in molecular neuroscience2021

Aerobic Exercise Training-Induced Changes on DNA Methylation in Mild Cognitively Impaired Elderly African Americans: Gene, Exercise, and Memory Study - GEMS-I.

Julius S Ngwa, Evaristus Nwulia, Oyonumo Ntekim, Fikru B Bedada, Bernard Kwabi-Addo, Sheeba Nadarajah, Steven Johnson, William M Southerland, John Kwagyan, Thomas O Obisesan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Exercise attenuates the hallmarks of aging: Novel perspectives.Journal of sport and health science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Julius S NgwaDivision of Cardiovascular Medicine, Department of Internal Medicine, Howard University, Washington, DC, United States.
Evaristus NwuliaDepartment of Psychiatry and Behavioral Sciences, Howard University, Washington, DC, United States.
Oyonumo NtekimDepartment of Nutritional Sciences, Howard University, Washington, DC, United States.
Fikru B BedadaDepartment of Clinical Laboratory Sciences, Howard University, Washington, DC, United States.
Bernard Kwabi-AddoDepartment of Biochemistry and Molecular Biology, Howard University, Washington, DC, United States.
Sheeba NadarajahDivision of Nursing, Howard University, Washington, DC, United States.
Steven JohnsonDivision of Geriatrics, Department of Medicine and Clinical/Translational Science Program, Howard University Hospital, Washington, DC, United States.
William M SoutherlandDepartment of Biochemistry and Molecular Biology, Howard University, Washington, DC, United States.
John KwagyanGeorgetown-Howard U Center for Clinical and Translation Science (GHUCCTS), Howard University Hospital, Washington, DC, United States.
Thomas O ObisesanDivision of Geriatrics, Department of Medicine and Clinical/Translational Science Program, Howard University Hospital, Washington, DC, United States.
Howard University · USHoward University Hospital · USGeorgetown-Howard Universities Center for Clinical and Translational Science · US

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
NCATS NIH HHS UL1 TR001409
6 · The paper itself

Abstract

backgroundDNA methylation at CpG sites is a vital epigenetic modification of the human genome affecting gene expression, and potentially, health outcomes. However, evidence is just budding on the effects of aerobic exercise-induced adaptation on DNA methylation in older mild cognitively impaired (MCI) elderly African American (AAs). Therefore, we examined the effects of a 6-month aerobic exercise-intervention on genome-wide DNA methylation in elderly AA MCI volunteers.

designElderly AA volunteers confirmed MCI assigned into a 6-month program of aerobic exercise (eleven participants) underwent a 40-min supervised-training 3-times/week and controls (eight participants) performed stretch training. Participants had maximal oxygen consumption (VO

resultsEleven MCI participants (aerobic: 73% females; mean age 72.3 ± 6.6 years) and eight MCI participants (stretch: 75% female; mean age 70.6 ± 6.7 years) completed the training. Aerobic exercise-training was associated with increases in VO

conclusionWe conclude that genome-wide DNA methylation patterns is associated with exercise training-induced methylation changes. Identification of methylation changes around genes previously shown to interact with amyloid biology, intracellular protein trafficking, and lipoprotein regulations provide further support to the likely protective effect of exercise in MCI. Future studies in larger samples are needed to confirm our findings.

Indexed as

African AmericansAlzheimer’s diseaseCPG IslandsDNA methylationmild cognitive impairmentVO2max

Identifiers

PMID35110995
PMCPMC8802631
OpenAlexW4205257365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.