ArticleNature2022
Autism genes converge on asynchronous development of shared neuron classes.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 260 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
260citing papers in PubMed, 3 pooled it
38.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
260 citing papers in PubMed, 3 syntheses or guidelines pooled it, 448 citations in OpenAlex.
- Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience.Advanced healthcare materials · 2026Pooled it
- Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus.Translational psychiatry · 2025Pooled it
- Brain volumes in genetic syndromes associated with mTOR dysregulation: a systematic review and meta-analysis.Molecular psychiatry · 2025Pooled it
- Differential GABA dynamics across brain functional networks in autism.Communications biology · 2026Trial
- Exploratory evidence for differences in GABAergic regulation of auditory processing in autism spectrum disorder.Translational psychiatry · 2023Trial
- PACS1 syndrome variant alters the proteomic landscape of developing cortical organoids.iScience · 2026Article
- Testing the Transferability of Perturbational Similarity Maps Across Species, Cell Systems, and Assay Modalities.Neuroinformatics · 2026Article
- Pathological Priming and Developmental Heterochrony as Organizing Concepts in Human iPSC Models of Autism Spectrum Disorder.Molecular neurobiology · 2026Review
- Disrupted PQBP1-HNRNPU-LINE-1 axis underlies aberrant neurodevelopment in renpenning syndrome.Molecular psychiatry · 2026Article
- CRISPR-Enabled functional genomics in hPSCs-derived neural models for autism spectrum disorder.Metabolic brain disease · 2026Review
- Elucidating the role of DEAF1 in neurodevelopment and shared molecular pathways in high-risk autism genes using cortical organoids.Science advances · 2026Article
- Systematic CRISPRi perturbation of 1,408 autism risk genes maps multilevel transcriptional convergence in human cortical neurons.bioRxiv : the preprint server for biology · 2026Article
- USP15 mutation associated with autism spectrum disorder alters progenitor fate and neuronal maturation in human brain organoids.Molecules and cells · 2026Article
- Article
- Organoid intelligence: a promising paradigm for autism spectrum disorder research.Molecular psychiatry · 2026Review
- The choroid plexus is a source of active renin in the central nervous system.Research square · 2026Article
- Mitochondrial-Epigenetic Crosstalk in Autism Spectrum Disorder: Linking Cellular Stress to Synaptic Dysfunction and Treatment Resistance.Molecular neurobiology · 2026Review
- Clinical, cellular, and genomic consequences of a population-enrichedResearch square · 2026Article
- From heterogeneity to translation: data‑driven subtyping of autism in a multilevel framework.Translational psychiatry · 2026Review
- Integrative functional genomics maps synaptic and developmental-regulatory autism risk-gene sets across human cortex.Functional & integrative genomics · 2026Article
200 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 6 institutions in 2 countries.
Bruna Paulsen *Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5304-0610
Silvia Velasco *Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. silvia.velasco@mcri.edu.au.ORCID http://orcid.org/0000-0003-0638-0932
Amanda J Kedaigle *Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6156-5046
Martina Pigoni *Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7896-6978
Giorgia QuadratoDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0717-4874
Anthony J DeoDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Xian AdiconisStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ana UzquianoDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Rafaela SartoreDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Sung Min YangDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Sean K SimmonsStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Panagiotis SymvoulidisMIT Center for Neurobiological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1396-3426
Kwanho KimDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-4448-3193
Kalliopi TsafouStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Archana PoduryMIT Center for Neurobiological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
Catherine AbbateDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Ashley TucewiczDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Samantha N SmithDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Alexandre AlbaneseInstitute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
Lindy BarrettDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-3229-4774
Neville E SanjanaStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Xi ShiStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Kwanghun ChungInstitute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8167-3340
Kasper LageStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6827-6239
Edward S BoydenMIT Center for Neurobiological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
Aviv RegevKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Joshua Z LevinStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0170-3598
Paola ArlottaDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. paola_arlotta@harvard.edu.ORCID http://orcid.org/0000-0003-2184-2277
Broad Institute · USHarvard University · USMassachusetts Institute of Technology · USHoward Hughes Medical Institute · USMcGovern Institute for Brain Research · USRutgers, The State University of New Jersey · US
Funding
Genetic neuroscience: How human genes and alleles shape neuronal phenotypesU01MH115727 · NIMH · BROAD INSTITUTE, INC. · PI ARLOTTA, PAOLA, BABADI, MEHRTASH · 2017 to 2021
$20.8MRes Support CoreP50MH094271 · NIMH · HARVARD UNIVERSITY · PI HENSCH, TAKAO K · 2011 to 2022
$18.6MModeling ASD-linked genetic mutations in 3D human brain organoidsR01MH112940 · NIMH · HARVARD UNIVERSITY · PI Paola Arlotta · 2018 to 2026
$5.2MHigh throughput assaying of circuit activity and connectivity in brain organoidsRF1MH123977 · NIMH · HARVARD UNIVERSITY · PI ARLOTTA, PAOLA, BOYDEN, EDWARD S. · 2020 to 2020
$2.5MFunctional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human NeuronsR21MH099448 · NIMH · BROAD INSTITUTE, INC. · PI PAN, JEN QIAN · 2012 to 2013
$467kHoward Hughes Medical InstituteNIMH NIH HHS P50 MH094271NIMH NIH HHS R01 MH112940NIMH NIH HHS R21 MH099448NIMH NIH HHS RF1 MH123977NIMH NIH HHS U01 MH115727
Abstract
Genetic risk for autism spectrum disorder (ASD) is associated with hundreds of genes spanning a wide range of biological functions
Indexed as
Autism Spectrum DisorderGenetic Predisposition to DiseaseNeuronsCerebral CortexDNA-Binding ProteinsGABAergic NeuronsHistone-Lysine N-MethyltransferaseHumansOrganoidsProteomicsRNA-SeqSingle-Cell AnalysisTranscription FactorsARID1B protein, humanCHD8 protein, humanDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseKMT5C protein, humanTranscription Factors
Identifiers
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