ArticleNature communications2022
Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 91 citations in OpenAlex.
- Unique adaptations in sulfatases underpin colonic mucin degradation by Akkermansia muciniphila.Nature microbiology · 2026Article
- Animal gut microbes and microbiomes in the 21st century and beyond.Science China. Life sciences · 2026Review
- Astrovirus infection alters gut microbial communities in a widespread neotropical bat across human-modified landscapes.BMC microbiology · 2026Article
- A comprehensive review on structural, chemical, and functional perspectives of dietary polysaccharide-driven gut microbiota modulation: Mechanisms and challenges.Biochemistry and biophysics reports · 2026Review
- Thermophilic Microbial Inoculant Promotes Lignocellulose Degradation During Green Waste Composting.Microorganisms · 2026Article
- Fecal virome of paraguayan hairy dwarf porcupine (Coendou spinosus, Cuvier, 1823) in Rio de Janeiro, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Fecal Material of Captive Wild Animals as Source of CAZymes With Application Potential.Chembiochem : a European journal of chemical biology · 2026Article
- Metagenomics reveals gut microbial differences and ecological adaptation in plateau zokor (Eospalax baileyi) populations.BMC microbiology · 2026Article
- Conformational gating mechanism for processive catalysis of β(1,3)-glucans.Nature communications · 2026Article
- Using Plant-Derived Polysaccharides in the Management of Cognitive Disorders: Molecular and Clinical Perspectives.Nutrients · 2026Review
- A disulfide redox switch mechanism regulates glycoside hydrolase function.Nature communications · 2026Article
- Article
- A molecular inventory of the faecal microbiomes of 23 marsupial species.Microbial genomics · 2026Article
- Microbial Biomarkers Differ for Various Feed Efficiency Metrics in Beef Cattle.Animals : an open access journal from MDPI · 2025Article
- UPGG: expanding the taxonomic and functional diversity of the pig gut microbiome with an enhanced genome catalog.NPJ biofilms and microbiomes · 2025Article
- Multi-omics reveal the gut microbiota-mediated severe foraging environment adaption of small wild ruminants in the Three-River-Source National Park, China.Integrative zoology · 2025Article
- Review
- The role of gut microbes in drought adaptation in the five-toed jerboa (Orientallactaga sibirica).BMC microbiology · 2025Article
- ez-CAZy a reference annotation database for linking glycoside hydrolase sequence to enzymatic activity.Scientific reports · 2025Article
- Optimization of Growth Conditions ofMicroorganisms · 2025Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The largest living rodent, capybara, can efficiently depolymerize and utilize lignocellulosic biomass through microbial symbiotic mechanisms yet elusive. Herein, we elucidate the microbial community composition, enzymatic systems and metabolic pathways involved in the conversion of dietary fibers into short-chain fatty acids, a main energy source for the host. In this microbiota, the unconventional enzymatic machinery from Fibrobacteres seems to drive cellulose degradation, whereas a diverse set of carbohydrate-active enzymes from Bacteroidetes, organized in polysaccharide utilization loci, are accounted to tackle complex hemicelluloses typically found in gramineous and aquatic plants. Exploring the genetic potential of this community, we discover a glycoside hydrolase family of β-galactosidases (named as GH173), and a carbohydrate-binding module family (named as CBM89) involved in xylan binding that establishes an unprecedented three-dimensional fold among associated modules to carbohydrate-active enzymes. Together, these results demonstrate how the capybara gut microbiota orchestrates the depolymerization and utilization of plant fibers, representing an untapped reservoir of enzymatic mechanisms to overcome the lignocellulose recalcitrance, a central challenge toward a sustainable and bio-based economy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.