Evidence map›Paper›PMID 35110484›Full record

ArticleInternal medicine (Tokyo, Japan)2022

IgA Nephropathy with Gross Hematuria Following COVID-19 mRNA Vaccination.

Yoshihito Nihei, Monami Kishi, Hitoshi Suzuki, Ayako Koizumi, Maiko Yoshida, Sho Hamaguchi, Masako Iwasaki, Hiromitsu Fukuda, Hisatsugu Takahara, Masao Kihara and 2 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Internal Medicine Year in Review 2022.Internal medicine (Tokyo, Japan) · 2023
    Article
  5. Article
  6. Article
  7. Immunoglobulin A nephropathy in remission: a case report.Annals of medicine and surgery (2012) · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Renal Complications Following COVID-19 Vaccination: A Narrative Literature Review.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yoshihito NiheiDepartment of Nephrology, Juntendo University Faculty of Medicine, Japan.
Monami KishiDepartment of Human Pathology, Juntendo University School of Medicine, Japan.
Hitoshi SuzukiDepartment of Nephrology, Juntendo University Faculty of Medicine, Japan.
Ayako KoizumiDepartment of Nephrology, Juntendo University Faculty of Medicine, Japan.
Maiko YoshidaDepartment of Nephrology, Juntendo University Faculty of Medicine, Japan.
Sho HamaguchiDepartment of Nephrology, Juntendo University Faculty of Medicine, Japan.
Masako IwasakiDepartment of Nephrology, Juntendo University Urayasu Hospital, Japan.
Hiromitsu FukudaDepartment of Nephrology, Juntendo University Urayasu Hospital, Japan.
Hisatsugu TakaharaDepartment of Nephrology, Juntendo University Urayasu Hospital, Japan.
Masao KiharaDepartment of Nephrology, Juntendo University Faculty of Medicine, Japan.
Shigeki TomitaDepartment of Human Pathology, Juntendo University School of Medicine, Japan.
Yusuke SuzukiDepartment of Nephrology, Juntendo University Faculty of Medicine, Japan.
Juntendo University · JPJuntendo University Urayasu Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 28-year-old woman experienced gross hematuria after the administration of the second dose of an messenger ribonucleic acid (mRNA) vaccine (BNT162b2). She was diagnosed with Immunogloblin A nephropathy (IgAN) by a renal biopsy two weeks after vaccination, which revealed a mild increase in mesangial cells and a matrix with co-depositions of galactose-deficient IgA1 and C3 in the mesangial region. The gross hematuria and proteinuria gradually improved without any medication, suggesting that immune activation by the mRNA vaccine may not elicit continuous disease progression of IgAN. Thus, further studies investigating the relationship between mRNA vaccines against COVID-19 and the progression of IgAN should be conducted.

Indexed as

COVID-19Glomerulonephritis, IGAAdultBNT162 VaccineCOVID-19 VaccinesFemaleHematuriaHumansImmunoglobulin AmRNA VaccinesRNA, MessengerVaccinationVaccines, SyntheticBNT162 VaccineCOVID-19 VaccinesImmunoglobulin AmRNA VaccinesRNA, MessengerVaccines, SyntheticCOVID-19gross hematuriaIgA nephropathymRNA vaccine

Identifiers

PMID35110484
PMCPMC9038465
OpenAlexW4210565204

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.