Evidence map›Paper›PMID 35110482›Full record

ReviewInternal medicine (Tokyo, Japan)2022

Severe Gastrointestinal Disorder Due to Capecitabine Associated with Dihydropyrimidine Dehydrogenase Deficiency: A Case Report and Literature Review.

Yuya Hagiwara, Yoshiyuki Yamamoto, Yuki Inagaki, Reina Tomisaki, Miki Tsuji, Soma Fukuda, Satoshi Fukuda, Tsubasa Onoda, Hirosumi Suzuki, Yusuke Niisato and 10 more

Open access · diamondAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Yuya HagiwaraDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Yoshiyuki YamamotoDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Yuki InagakiDepartment of Gastrointestinal Surgery, Tsukuba Medical Center Hospital, Japan.
Reina TomisakiDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Miki TsujiDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Soma FukudaDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Satoshi FukudaDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Tsubasa OnodaDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Hirosumi SuzukiDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Yusuke NiisatoDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Yoshitaka TangeDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Naoya IkedaDepartment of Gastrointestinal Surgery, Tsukuba Medical Center Hospital, Japan.
Keiichi YamadaDepartment of Gastrointestinal Surgery, Tsukuba Medical Center Hospital, Japan.
Mariko KobayashiDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Daisuke AkutsuDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Takeshi YamadaDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Toshikazu MoriwakiDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Toshiaki NarasakaDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Hideo SuzukiDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
Kiichiro TsuchiyaDepartment of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.
University of Tsukuba · JPTsukuba Medical Center Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dihydropyrimidine dehydrogenase (DPD) deficiency induces severe adverse events in patients receiving fluoropyrimidines. We encountered a 64-year-old DPD-deficient man with a severe capecitabine-related gastrointestinal disorder. He received capecitabine-containing chemotherapy after rectal cancer resection. During the first course of chemotherapy, he developed severe diarrhea, a fever, and hematochezia. Endoscopy revealed mucosal shedding with bleeding throughout the gastrointestinal tract. DPD deficiency was suspected because he developed many severe adverse events of capecitabine early and was finally confirmed based on the finding of a low DPD activity level in peripheral blood mononuclear cells. After one month of intensive care, hemostasis and mucosal healing were noted, although his gastrointestinal function did not improve, and he had persistent nutritional management issues.

Indexed as

Dihydropyrimidine Dehydrogenase DeficiencyRectal NeoplasmsAntimetabolites, AntineoplasticCapecitabineFluorouracilHumansLeukocytes, MononuclearMaleMiddle AgedAntimetabolites, AntineoplasticCapecitabineFluorouraciladverse eventcapecitabinedihydropyrimidine dehydrogenase (DPD) deficiencygastrointestinal bleedinggastrointestinal disorder

Identifiers

PMID35110482
PMCPMC9449621
OpenAlexW4210534174

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.