ArticleProceedings of the National Academy of Sciences of the United States of America2022
Tracing the cis-regulatory changes underlying the endometrial control of placental invasion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Stromal resistance to placental invasion is a derived trait in ruminants.The Journal of reproduction and development · 2026Review
- GATA2-driven ZNF486-JAM2 activation collaboratively counteracts epithelial-mesenchymal transition andFrontiers in oncology · 2026Article
- Identifying genes underlying parallel evolution of stromal resistance to placental and cancer invasion.NPJ systems biology and applications · 2025Article
- Extravillous trophoblasts reverse the decidualization induced increase in matrix production by secreting TGFβ antagonists Emilin-1 and Gremlin-1.Cells & development · 2025Article
- Scar matrix drives Piezo1 mediated stromal inflammation leading to placenta accreta spectrum.Nature communications · 2024Article
- Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta.Biology of sex differences · 2024Article
- Lightsheet microscopy integrates single-cell optical visco-elastography and fluorescence cytometry of 3D live tissues.bioRxiv : the preprint server for biology · 2024Article
- Article
- Experimental and phylogenetic evidence for correlated gene expression evolution in endometrial and skin fibroblasts.iScience · 2024Article
- Human embryo implantation.Development (Cambridge, England) · 2023Review
- The value of broad taxonomic comparisons in evolutionary medicine: Disease is not a trait but aMedComm · 2022Article
- Female Health Across the Tree of Life: Insights at the Intersection of Women's Health, One Health and Planetary Health.PNAS nexus · 2022Article
- Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Among eutherian (placental) mammals, placental embedding into the maternal endometrium exhibits great differences, from being deeply invasive (e.g., humans) to noninvasive (e.g., cattle). The degree of invasion of placental trophoblasts is positively correlated with the rate of cancer malignancy. Previously, we have shown that fibroblasts from different species offer different levels of resistance to the invading trophoblasts as well as to cancer cell invasion. Here we present a comparative genomic investigation revealing cis-regulatory elements underlying these interspecies differences in invasibility. We identify transcription factors that regulate proinvasibility and antiinvasibility genes in stromal cells. Using an in vitro invasibility assay combined with CRISPR-Cas9 gene knockout, we found that the transcription factors GATA2 and TFDP1 strongly influence the invasibility of endometrial and skin fibroblasts. This work identifies genomic mechanisms explaining species differences in stromal invasibility, paving the way to therapies targeting stromal characteristics to regulate placental invasion, wound healing, and cancer dissemination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.