Evidence map›Paper›PMID 35110348›Full record

ArticleSaudi medical journal2022

Prothrombin complex concentrate in the management of major bleeding induced by oral anticoagulant therapy.

Mohammed AlSheef, Ghaydaa Kullab, Modhi Alajmi, Ruba Aldhaheri, Sultan Al Baqmi, Haya Alajlan, Abdul Rehman Z Zaidi, Amani Abu-Shaheen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mohammed AlSheefFrom the Medical Specialties Department (AlSheef), from the Internal Medicine Department (Kullab), from the Research Center (Abu-Shaheen), King Fahad Medical City; from the Internal Medicine Department (Kullab, Zaidi), Dr. Sulaiman Al Habib Medical Group, Riyadh; from the College of Medicine (Al Baqmi), King Saud Bin Abdulaziz University for Health Sciences; from the College of Health and Rehabilitation Sciences (Alajlan), Princess Noura Bint Mohammed University, Riyadh; from the College of Medicine (Alajmi), Imam Abdulrahman Bin Faisal University, Dammam; and from the College of Medicine (Aldhaheri), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Ghaydaa KullabFrom the Medical Specialties Department (AlSheef), from the Internal Medicine Department (Kullab), from the Research Center (Abu-Shaheen), King Fahad Medical City; from the Internal Medicine Department (Kullab, Zaidi), Dr. Sulaiman Al Habib Medical Group, Riyadh; from the College of Medicine (Al Baqmi), King Saud Bin Abdulaziz University for Health Sciences; from the College of Health and Rehabilitation Sciences (Alajlan), Princess Noura Bint Mohammed University, Riyadh; from the College of Medicine (Alajmi), Imam Abdulrahman Bin Faisal University, Dammam; and from the College of Medicine (Aldhaheri), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Modhi AlajmiFrom the Medical Specialties Department (AlSheef), from the Internal Medicine Department (Kullab), from the Research Center (Abu-Shaheen), King Fahad Medical City; from the Internal Medicine Department (Kullab, Zaidi), Dr. Sulaiman Al Habib Medical Group, Riyadh; from the College of Medicine (Al Baqmi), King Saud Bin Abdulaziz University for Health Sciences; from the College of Health and Rehabilitation Sciences (Alajlan), Princess Noura Bint Mohammed University, Riyadh; from the College of Medicine (Alajmi), Imam Abdulrahman Bin Faisal University, Dammam; and from the College of Medicine (Aldhaheri), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Ruba AldhaheriFrom the Medical Specialties Department (AlSheef), from the Internal Medicine Department (Kullab), from the Research Center (Abu-Shaheen), King Fahad Medical City; from the Internal Medicine Department (Kullab, Zaidi), Dr. Sulaiman Al Habib Medical Group, Riyadh; from the College of Medicine (Al Baqmi), King Saud Bin Abdulaziz University for Health Sciences; from the College of Health and Rehabilitation Sciences (Alajlan), Princess Noura Bint Mohammed University, Riyadh; from the College of Medicine (Alajmi), Imam Abdulrahman Bin Faisal University, Dammam; and from the College of Medicine (Aldhaheri), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Sultan Al BaqmiFrom the Medical Specialties Department (AlSheef), from the Internal Medicine Department (Kullab), from the Research Center (Abu-Shaheen), King Fahad Medical City; from the Internal Medicine Department (Kullab, Zaidi), Dr. Sulaiman Al Habib Medical Group, Riyadh; from the College of Medicine (Al Baqmi), King Saud Bin Abdulaziz University for Health Sciences; from the College of Health and Rehabilitation Sciences (Alajlan), Princess Noura Bint Mohammed University, Riyadh; from the College of Medicine (Alajmi), Imam Abdulrahman Bin Faisal University, Dammam; and from the College of Medicine (Aldhaheri), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Haya AlajlanFrom the Medical Specialties Department (AlSheef), from the Internal Medicine Department (Kullab), from the Research Center (Abu-Shaheen), King Fahad Medical City; from the Internal Medicine Department (Kullab, Zaidi), Dr. Sulaiman Al Habib Medical Group, Riyadh; from the College of Medicine (Al Baqmi), King Saud Bin Abdulaziz University for Health Sciences; from the College of Health and Rehabilitation Sciences (Alajlan), Princess Noura Bint Mohammed University, Riyadh; from the College of Medicine (Alajmi), Imam Abdulrahman Bin Faisal University, Dammam; and from the College of Medicine (Aldhaheri), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Abdul Rehman Z ZaidiFrom the Medical Specialties Department (AlSheef), from the Internal Medicine Department (Kullab), from the Research Center (Abu-Shaheen), King Fahad Medical City; from the Internal Medicine Department (Kullab, Zaidi), Dr. Sulaiman Al Habib Medical Group, Riyadh; from the College of Medicine (Al Baqmi), King Saud Bin Abdulaziz University for Health Sciences; from the College of Health and Rehabilitation Sciences (Alajlan), Princess Noura Bint Mohammed University, Riyadh; from the College of Medicine (Alajmi), Imam Abdulrahman Bin Faisal University, Dammam; and from the College of Medicine (Aldhaheri), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Amani Abu-ShaheenFrom the Medical Specialties Department (AlSheef), from the Internal Medicine Department (Kullab), from the Research Center (Abu-Shaheen), King Fahad Medical City; from the Internal Medicine Department (Kullab, Zaidi), Dr. Sulaiman Al Habib Medical Group, Riyadh; from the College of Medicine (Al Baqmi), King Saud Bin Abdulaziz University for Health Sciences; from the College of Health and Rehabilitation Sciences (Alajlan), Princess Noura Bint Mohammed University, Riyadh; from the College of Medicine (Alajmi), Imam Abdulrahman Bin Faisal University, Dammam; and from the College of Medicine (Aldhaheri), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Imam Abdulrahman Bin Faisal University · SAKing Fahd Medical City · SAPrincess Nourah bint Abdulrahman University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo share clinical data on the efficacy of 4F-PCC in the treatment of major bleeding caused by warfarin, dabigatran, and rivaroxaban.

methodsThis is a retrospective study of patients admitted to King Fahad Medical City, Riyadh, Saudi Arabia with major bleeding caused by oral anticoagulants and treated with 4-factor prothrombin complex concentrate (4F-PCC). The International Society of Thrombosis and Hemostasis Scientific and Standardization Subcommittee criteria were used to evaluate the effectiveness of PCCs.

resultsA total of 22 patients were included in the study. Ten of the events were caused by gastrointestinal bleeding (46%). In the majority of patients, anticoagulation was prescribed for stroke prevention, atrial fibrillation, and venous thromboembolism. The median international normalized ratio was significantly lower before and after PCC administration (

conclusionProthrombin complex concentrate can effectively reverse the effects of warfarin and rivaroxaban in patients with major bleeding, but only partially reverses the effect of dabigatran.

Indexed as

AnticoagulantsBlood Coagulation FactorsGastrointestinal HemorrhageHumansRetrospective StudiesAnticoagulantsBlood Coagulation Factorsprothrombin complex concentratesISTH criteriaPCCrivaroxabanwarfarin

Identifiers

PMID35110348
PMCPMC9127923
OpenAlexW4210813540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.