Evidence map›Paper›PMID 35110337›Full record

ArticleSaudi medical journal2022

Lack of association between fat mass and obesity-associated genetic variant (rs8050136) and type 2 diabetes mellitus.

Amjad M Yousuf, Firoz A Kannu, Talha M Youssouf, Fatimah N Alsuhaimi, Abdulaziz M Aljohani, Fayez H Alsehli, Omar F Khabour, Yahya A Almutawif, Mustafa A Najim, Hatem A Mahmood

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In one paragraph

Article in Saudi medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Amjad M YousufFrom the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, Najim), College of Applied Medical Sciences, Taibah University; from the General Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Firoz A KannuFrom the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, Najim), College of Applied Medical Sciences, Taibah University; from the General Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Talha M YoussoufFrom the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, Najim), College of Applied Medical Sciences, Taibah University; from the General Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Fatimah N AlsuhaimiFrom the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, Najim), College of Applied Medical Sciences, Taibah University; from the General Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Abdulaziz M AljohaniFrom the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, Najim), College of Applied Medical Sciences, Taibah University; from the General Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Fayez H AlsehliFrom the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, Najim), College of Applied Medical Sciences, Taibah University; from the General Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Omar F KhabourFrom the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, Najim), College of Applied Medical Sciences, Taibah University; from the General Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Yahya A AlmutawifFrom the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, Najim), College of Applied Medical Sciences, Taibah University; from the General Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Mustafa A NajimFrom the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, Najim), College of Applied Medical Sciences, Taibah University; from the General Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Hatem A MahmoodFrom the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, Najim), College of Applied Medical Sciences, Taibah University; from the General Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo study the genotype and allele frequency of the fat mass and obesity-associated (FTO) rs8050136 A>C genetic variant and investigate its association with type 2 diabetes mekkitus (T2DM) parameters.

methodsThis study was carried out on 118 diabetic patients and 106 healthy individuals (control) from Prince Mohammed bin Abdulaziz Hospital, Al Madinah Al Munawarah, Saudi Arabia. The TaqMan single-nucleotide polymorphism (SNP)genotyping assay was used for rs8050136 genotyping.

resultsThe frequency of the genotype AA was the same among T2DM and healthy control groups (21%). However, the frequency of genotype CC was 19.5% in T2DM patients and 24.5% in control individuals. There was no significant association between FTO SNP rs8050136 and an increased risk of T2DM. Furthermore, there was no association between the risk AA genotype and fasting blood glucose (

conclusionOur findings show that the FTO rs8050136 A>C variant is not associated with T2DM in the Saudi population.

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTODiabetes Mellitus, Type 2Body Mass IndexHumansPolymorphism, Single NucleotideSaudi ArabiaAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanallele frequencyFTO genegene variantGWAStype 2 diabetes

Identifiers

PMID35110337
PMCPMC9127913

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.