Evidence map›Paper›PMID 35110317›Full record

Observational studyBMJ open2022

Quantitative assessment of pregnancy outcome following recurrent miscarriage clinic care: a prospective cohort study.

Rebecca Shields, Omar Khan, Sarah Lim Choi Keung, Amelia Jane Hawkes, Aisling Barry, Adam J Devall, Stephen D Quinn, Stephen D Keay, Theodoros N Arvanitis, Debra Bick and 1 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Rebecca ShieldsDivision of Reproductive Health, University of Warwick, Coventry, UK rebecca.shields@uhcw.nhs.uk.ORCID 0000-0002-7442-5242
Omar KhanInstitute of Digital Healthcare, University of Warwick, Coventry, UK.
Sarah Lim Choi KeungInstitute of Digital Healthcare, University of Warwick, Coventry, UK.
Amelia Jane HawkesDivision of Reproductive Health, University of Warwick, Coventry, UK.
Aisling BarryWarwick Medical School, University of Warwick, Coventry, UK.
Adam J DevallTommy's National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Stephen D Quinn5. Tommy's National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, Imperial College London, London, UK.
Stephen D KeayCentre for Reproductive Medicine, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
Theodoros N ArvanitisInstitute of Digital Healthcare, University of Warwick, Coventry, UK.ORCID 0000-0001-5473-135X
Debra BickWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.ORCID 0000-0002-8557-7276
Siobhan QuenbyTommy's National Centre for Miscarriage Research, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
University of Warwick · GBUniversity Hospitals Coventry and Warwickshire NHS Trust · GBMiscarriage Association · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo measure pregnancy outcome following attendance at a recurrent miscarriage service and identify factors that influence outcome.

designProspective, observational electronic cohort study.

settingParticipants attending a specialist recurrent miscarriage clinic, with a history of two or more pregnancy losses. 857 new patients attended over a 30-month period and were invited to participate. Participant data were recorded on a bespoke study database, 'Tommy's Net'.

participants777 women consented to participate (90.7% of new patients). 639 (82%) women continued within the cohort, and 138 were lost to follow-up. Mean age of active participants was 34 years for women and 37 years for partners, with a mean of 3.5 (1-19) previous pregnancy losses. Rates of obesity (maternal: 23.8%, paternal: 22.4%), smoking (maternal:7.4%, paternal: 19.4%) and alcohol consumption (maternal: 50%, paternal: 79.2%) were high and 55% of participants were not taking folic acid. OUTCOME MEASURES: Biannual collection of pregnancy outcomes, either through prompted self-reporting, or existing hospital systems.

results639 (82%) women were followed up. 404 (83.4%) reported conception and 106 (16.6%) reported no pregnancy, at least 6 months following registration. Of those that conceived, 72.8% (294/404) had a viable pregnancy. Maternal smoking and body mass index (BMI) over 30 were significantly higher in those who did not conceive (p=0.001)

conclusionsTommy's Net provides a secure electronic repository on data for couples with recurrent pregnancy loss and associated outcomes. The study identified that subfertility, as well as repeated miscarriage, maternal BMI and smoking status, contributed to failure to achieve live birth. Study findings may enable comparison of clinic outcomes and inform the development of a personalised holistic care package.

Indexed as

Abortion, HabitualPregnancy OutcomeAdultCohort StudiesFemaleHumansLive BirthPregnancyProspective Studiesgynaecologyobstetricsreproductive medicinesubfertility

Identifiers

PMID35110317
PMCPMC8811565
OpenAlexW4220933029

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.