Evidence map›Paper›PMID 35110312›Full record

ArticleBMJ open2022

Sunshine on KOLs: assessment of the nature, extent and evolution of financial ties between the leaders of professional medical associations and the pharmaceutical industry in France from 2014 to 2019: a retrospective study.

Marie Clinckemaillie, Alexandre Scanff, Florian Naudet, Adriaan Barbaroux

Abstract read
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Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marie ClinckemaillieDépartement d'Enseignement et de Recherche en Médecine Générale, RETINES, HEALTHY, Université Côte d'Azur, Nice, France.
Alexandre ScanffCHU Rennes, Inserm, CIC 1414 [(Centre d'Investigation Clinique de Rennes)], Université de Rennes, Rennes, France.ORCID 0000-0001-5419-817X
Florian NaudetClinical Investigation Center (INSERM 1414) and Adult Psychiatry Department, Rennes University Hospital, Rennes 1 University, Rennes, Bretagne, France.ORCID 0000-0003-3760-3801
Adriaan BarbarouxDépartement d'Enseignement et de Recherche en Médecine Générale, RETINES, LAPCOS, HEALTHY, Université Côte d'Azur, Nice, France adriaan.barbaroux@univ-cotedazur.fr.ORCID 0000-0002-9243-6922

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the financial relationships between key opinion leader (KOL) or non-KOL physicians and pharmaceutical and device companies in France.

designRetrospective and descriptive study.

settingAll doctors practising in France, with a focus on 548 KOLs (board members of the professional medical associations that published guidelines in 2018-2019, identified on the associations' websites between 2018 and 2020). Ties were collected from the 'Transparency in Healthcare' database.

main outcome measuresThe number and the value of gifts from 2014 to 2019, and of remunerations and contractual agreements from 2017 to 2019.

resultsKOLs represented 0.24% of the total number of physicians in France. The total value of gifts declared in the French database for all physicians amounted to €818M (US$936M, £741M). At least one gift was declared for 83% of KOLs. KOLs' gifts represented 0.68% of the total number of gifts to physicians and 1.5% of the total value of gifts, with a mean of €3700 per capita per year.The total value of contractual agreements declared for all physicians amounted to €125M. Contractual agreements involving the KOLs represented 0.72% of the number of contractual agreements with physicians and 2.5% of the value of the agreements, with a mean of €1900 per capita per year.A total of €156M in remunerations were declared for all physicians. KOL remunerations represented 2.3% of the number of physician remunerations and 4.4% of the total value of the remunerations paid to physicians, with a mean of €4100 per capita per year.Almost all professional medical associations (99%) had at least one KOL in their board with a financial tie to the industry, but the amount varied widely among the associations.

conclusionFinancial relationships between KOLs and the industry in France are extensive. KOLs have much more financial ties than non-KOL practitioners.

Indexed as

Drug IndustryPhysiciansConflict of InterestDatabases, FactualGift GivingHumansRetrospective Studiesethics (see medical ethics)health economicspublic healthquality in health care

Identifiers

PMID35110312
PMCPMC8811544

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.