Evidence map›Paper›PMID 35109986›Full record

ArticleThe Journal of investigative dermatology2022

Loss of TET2 Tips the Scales Toward Tumorigenesis.

Brian C Capell

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of investigative dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Brian C CapellDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: capellb@pennmedicine.upenn.edu.
University of Pennsylvania · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3M
Epigenetic enhancer control in maintaining homeostasis and preventing carcinogenesis in the epidermisR01AR077615 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI CAPELL, BRIAN · 2020 to 2024
$2.1M
NIAMS NIH HHS R01 AR077615NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

DNA methylation and demethylation function in the balance between cellular differentiation and cancer. Although the roles of DNA methyltransferases have been extensively explored in epidermal biology, ten-eleven translocation (TET) demethylase enzymes are poorly understood. In their new article in the Journal of Investigative Dermatology, Boudra et al. present evidence for a tumor-suppressive role of TET2 and its regulation of 5-hydroxymethylcytosine in the prevention of squamous cell carcinomas.

Indexed as

Carcinoma, Squamous CellDioxygenases5-MethylcytosineCell Transformation, NeoplasticDNA-Binding ProteinsDNA MethylationHumansProto-Oncogene Proteins5-MethylcytosineDioxygenasesDNA-Binding ProteinsProto-Oncogene ProteinsTET2 protein, human

Identifiers

PMID35109986
PMCPMC9128576
OpenAlexW4210349278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.