Active IgG4-related disease with bone marrow involvement: a report of 2 cases and case-based review.

Shiyi Liu, Hui Wang, Tao Su

Open access · goldAbstract readCase ReportsReview

In one paragraph

Review in European journal of medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.5field-weighted citation impact, top 36% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Cytopenias in Autoimmune Liver Diseases-A Review.Journal of clinical medicine · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Shiyi LiuRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.

Hui WangLaboratory of Electron Microscopy, Peking University First Hospital, Beijing, China.

Tao SuRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China. tao.su@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-6857-8146

Peking University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

National Major Science and Technology Projects of China 2017ZX09304028

6 · The paper itself

Abstract

IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory disease, histopathologically characterized by dense lymphoplasmacytic infiltration rich in IgG4-positive plasma cells in affected organs. Classic hematologic presentations including lymphadenopathy, eosinophilia and polyclonal hypergammaglobulinemia are common, whereas bone marrow involvement of IgG4-RD is rarely reported. Here we present two patients of multi-organ IgG4-RD with bone marrow involvement, one on bone marrow biopsy, and the other on PET/CT. Presentations of other organ involvement included biopsy-proven IgG4-related tubulointerstitial nephritis, lymphadenopathies, submaxillary glands, arteritis, asthma, dysosmia, and constitutional symptoms. Bone marrow involvement was initially suspected due to leukopenia, anemia and thrombocytopenia in case#1, and was finally confirmed by histological evidence of significant IgG4-positive plasma cells infiltration in bone marrow. In case#2, we incidentally observed high uptakes of multi-bone marrow on

Indexed as

AdultAgedBiopsyBone MarrowHumansImmunoglobulin G4-Related DiseaseMalePositron Emission Tomography Computed Tomography18F-FDG-PET/CTBone marrowHematologicIgG4-related diseaseLeukopeniaThrombocytopenia

Identifiers

PMID35109941

DOI10.1186/s40001-022-00643-w

PMCPMC8808987

OpenAlexW4210419381

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.