Evidence map›Paper›PMID 35109931›Full record

ReviewBiomaterials research2022

Shape-controlled synthesis of zinc nanostructures mediating macromolecules for biomedical applications.

Seyyed Mojtaba Mousavi, Gity Behbudi, Ahmad Gholami, Seyyed Alireza Hashemi, Zohre Mousavi Nejad, Sonia Bahrani, Wei-Hung Chiang, Lai Chin Wei, Navid Omidifar

Open access · goldAbstract readReview
In one paragraph

Review in Biomaterials research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Article
  3. Bioinspired 8‑hydroxyquinoline-FeScientific reports · 2026
    Article
  4. Review
  5. Applications and prospects of biomaterials in diabetes management.Frontiers in bioengineering and biotechnology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Seyyed Mojtaba MousaviDepartment of Chemical Engineering, National Taiwan University of Science and Technology, Taipei City, Taiwan.
Gity BehbudiDepartment of Chemical Engineering, University of Mohaghegh Ardabili, Ardabil, Iran.
Ahmad GholamiBiotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. gholami@sums.ac.ir.ORCID http://orcid.org/0000-0003-1851-159X
Seyyed Alireza HashemiNanomaterials and Polymer Nanocomposites Laboratory, School of Engineering, University of British Columbia, Kelowna, BC, V1V 1V7, Canada.
Zohre Mousavi NejadBiotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Sonia BahraniBiotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Wei-Hung ChiangDepartment of Chemical Engineering, National Taiwan University of Science and Technology, Taipei City, Taiwan. whchiang@mail.ntust.edu.tw.
Lai Chin WeiNanotechnology & Catalysis Research Centre, University of Malaya, Kuala Lumpur, Malaysia.
Navid OmidifarDepartment of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IRNational Taiwan University of Science and Technology · TWUniversity of British Columbia · CAUniversity of Malaya · MYUniversity of Mohaghegh Ardabili · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc nanostructures (ZnONSs) have attracted much attention due to their morphological, physicochemical, and electrical properties, which were entailed for various biomedical applications such as cancer and diabetes treatment, anti-inflammatory activity, drug delivery. ZnONS play an important role in inducing cellular apoptosis, triggering excess reactive oxygen species (ROS) production, and releasing zinc ions due to their inherent nature and specific shape. Therefore, several new synthetic organometallic method has been developed to prepare ZnO crystalline nanostructures with controlled size and shape. Zinc oxide nanostructures' crystal size and shape can be controlled by simply changing the physical synthesis condition such as microwave irradiation time, reaction temperature, and TEA concentration at reflux. Physicochemical properties which are determined by the shape and size of ZnO nanostructures, directly affect their biological applications. These nanostructures can decompose the cell membrane and accumulate in the cytoplasm, which leads to apoptosis or cell death. In this study, we reviewed the various synthesis methods which affect the nano shapes of zinc particles, and physicochemical properties of zinc nanostructures that determined the shape of zinc nanomaterials. Also, we mentioned some macromolecules that controlled their physicochemical properties in a green and biological approaches. In addition, we present the recent progress of ZnONSs in the biomedical fields, which will help centralize biomedical fields and assist their future research development.

Indexed as

Biomedical applicationsMacromoleculesReactive oxidative stressShape controlled zinc oxide nanostructures

Identifiers

PMID35109931
PMCPMC8812270
OpenAlexW4210380903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.