SynthesisJournal of orthopaedic surgery and research2022
3D-printed porous Ti6Al4V scaffolds for long bone repair in animal models: a systematic review.
Synthesis in Journal of orthopaedic surgery and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Modular Revision of a Failed Patient-Specific 3D-Printed Scapulo-Humeral Endoprosthesis in a Dog with Proximal Humeral Osteosarcoma: First Clinical Communication.Animals : an open access journal from MDPI · 2026Article
- Feasibility of Ti-6Al-4V Alloys with Nanoporous and Nanotubular Surfaces for the Treatment of Femoral Defects.International journal of molecular sciences · 2026Article
- Cellular metabolomics reveals the osteogenic mechanism of MC3T3-E1 cells in porous Ti6Al4V scaffolds under low-intensity pulsed ultrasound.Frontiers in cell and developmental biology · 2026Article
- In-house 3D printed porous implants: does strontium-coating enhance osseointegration? AnFrontiers in surgery · 2026Article
- Early osseointegration of two in-house 3D-printed porous titanium implant designs: anFrontiers in surgery · 2026Article
- Reconstruction of a large distal femoral giant cell tumor using a 3D-printed condylar support lattice metal implant and fibular grafts: a novel biomechanical and surgical approach.3D printing in medicine · 2025Article
- Mid-term comparison of highly porous versus hydroxyapatite-coated porous surface in the same cup system: a retrospective single-center study.BMC musculoskeletal disorders · 2025Article
- Applying 3D-Printed Porous Ti6Al4V Prostheses to Repair Osteomyelitis-Induced Partial Bone Defects of Lower Limbs: Finite Element Analysis and Clinical Outcomes.Orthopaedic surgery · 2025Article
- Utilizing biomaterial surface properties to improve orthopedic hip implant safety and function in a Safe-by-Design approach.Frontiers in bioengineering and biotechnology · 2025Review
- Bone Ingrowth Simulation Within the Hexanoid, a Novel Scaffold Design.3D printing and additive manufacturing · 2024Article
- Article
- Biomechanical Properties of Novel Porous Scaffold Core and Hollow Lateral Hole Pedicle Screws: A Comparative Study in Bama Pigs.Orthopaedic surgery · 2024Article
- Article
- Bio-functional hydroxyapatite-coated 3D porous polyetherketoneketone scaffold for enhanced osteogenesis and osteointegration in orthopedic applications.Regenerative biomaterials · 2024Article
- Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone Scaffolds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Continuously released ZnBioactive materials · 2023Article
- Study of the Effect of Anodic Oxidation on the Corrosion Properties of the Ti6Al4V Implant Produced from SLM.Journal of functional biomaterials · 2023Article
- Coating of manganese functional polyetheretherketone implants for osseous interface integration.Frontiers in bioengineering and biotechnology · 2023Article
- "Metal-bone" scaffold for accelerated peri-implant endosseous healing.Frontiers in bioengineering and biotechnology · 2023Article
- Application of Biocompatible Scaffolds in Stem-Cell-Based Dental Tissue Engineering.Advances in experimental medicine and biology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTitanium and its alloys have been widely employed for bone tissue repair and implant manufacturing. The rapid development of three-dimensional (3D) printing technology has allowed fabrication of porous titanium scaffolds with controllable microstructures, which is considered to be an effective method for promoting rapid bone formation and decreasing bone absorption. The purpose of this systematic review was to evaluate the osteogenic potential of 3D-printed porous Ti6Al4V (Ti64) scaffold for repairing long bone defects in animal models and to investigate the influential factors that might affect its osteogenic capacity.
methodsElectronic literature search was conducted in the following databases: PubMed, Web of Science, and Embase up to September 2021. The SYRCLE's tool and the modified CAMARADES list were used to assess the risk of bias and methodological quality, respectively. Due to heterogeneity of the selected studies in relation to protocol and outcomes evaluated, a meta-analysis could not be performed.
resultsThe initial search revealed 5858 studies. Only 46 animal studies were found to be eligible based on the inclusion criteria. Rabbit was the most commonly utilized animal model. A pore size of around 500-600 µm and porosity of 60-70% were found to be the most ideal parameters for designing the Ti64 scaffold, where both dodecahedron and diamond pores optimally promoted osteogenesis. Histological analysis of the scaffold in a rabbit model revealed that the maximum bone area fraction reached 59.3 ± 8.1% at weeks 8-10. Based on micro-CT assessment, the maximum bone volume fraction was found to be 34.0 ± 6.0% at weeks 12.
conclusionsTi64 scaffold might act as a promising medium for providing sufficient mechanical support and a stable environment for new bone formation in long bone defects. Trail registration The study protocol was registered in the PROSPERO database under the number CRD42020194100.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.